Figure 1
From: Growth hormone exacerbates diabetic renal damage in male but not female rats
Effect of sex on GSI in Control and diabetic rats treated with and without GH. (A) STZ treatment significantly increased the GSI in both sexes, while GH treatment significantly increased GSI beyond STZ alone in males only.* P < 0.01 vs. control of the respective sex, # P < 0.05 vs male STZ. (B) Representative pictures of periodic acid Schiff-stained sections. Diabetic kidneys were characterized by moderate glomerulosclerosis, as evidenced by mesangial expansion (arrowheads), and is seen more abundantly in male STZ + GH than STZ alone. Original magnification is × 400, and bar represents 100 μm.