Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood

Table 5 Summary of the proposed role of HNF4α and pituitary hormone in developmental changes in liver gene expression

This table summarizes the findings presented in Table 2, Table 3, and Additional files 6A-B. A plus sign indicates positive regulation and a minus sign indicates negative regulation. In male liver, HNF4α and pituitary hormone positively regulate male-specific genes that are up regulated from 3 to 8 wk; both factors also negatively regulate female-specific genes that are down regulated from 3 to 8 wk. In female liver, HNF4α positively regulates developmentally up regulated male-specific and female-specific genes, while negatively regulating developmentally down regulated male-specific genes. HNF4α and pituitary hormone exhibited similar patterns of regulation of sex-independent genes in male as in female liver, except that pituitary hormone showed both positive regulation and negative regulation of the developmentally up regulated sex-independent genes in female liver only

ISSN: 2042-6410