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Figure 4 | Biology of Sex Differences

Figure 4

From: Sex-specific signaling through Toll-Like Receptors 2 and 4 contributes to survival outcome of Coxsackievirus B3 infection in C57Bl/6 mice

Figure 4

Mean Fluorescent Intensity (MFI) data shows sex differences in TLR2 protein expression on lymphocyte populations. Female mice have higher levels of TLR2 expression on CD3+ cells at Day 6 (p=<0.001) compared to male mice. In addition, CD4+ cells isolated from female mice have higher levels of TLR2 expression at all three timepoints compared to males (p=0.001, 0.001, and 0.006 respectively). In contrast, male mice have higher levels of TLR2 expression on macrophage populations at Day 3 (p=0.006) and Day 6 (p=<0.001) relative to female mice. Male mice also show greater expression of TLR2 on dendritic cells at all three timepoints (p=0.002, <<0.001, and 0.006 respectively). Numbers of mice used in this experiment were as follows: Male D6=6, D3=3, D0=3; Female D6=5, D3=4, D0=5.

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