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Table 2 Univariable and multivariable analyses of factors associated with disease free survival in the full cohort, women and men

From: Modifying effect of gender on the prognostic value of clinicopathological factors and Ki67 expression in melanoma: a population-based cohort study

Disease free survival Univariable Multivariable
All HR(95%CI) Women HR(95%CI) Men HR(95%CI) All HR(95%CI) Women HR(95%CI) Men HR(95%CI)
Age       
Continuous 1.01 (0.97-1.05) 1.00 (0.95-1.05) 1.01 (0.95-1.07) 0.98 (0.94-1.02) 1.00 (0.94-1.06) 1.00 (0.92-1.09)
Sex       
Women 1.00 - - 1.00 - -
Men 1.51 (0.85-2.70) - - 1.06 (0.52-2.15) - -
Histological subtype       
LMM + SSM 1.00 1.00 1.00 1.00 1.00 1.00
NMM 5.63 (3.15-10.08) 6.36 (2.67-15.12) 5.39 (2.41-12.09) 1.21 (0.55-2.63) 1.47 (0.48-4.54) 1.49 (0.46-4.82)
Breslow thickness       
<=1 mm 1.00 1.00 1.00 1.00 1.00 1.00
> 1 mm 8.44 (4.27-16.68) 12.17 (4.07-36.34) 6.12 (2.14-14.73 0.61 (0.10-3.70) 0.17 (0.01-2.95) 1.45 (0.15-14.22)
Clark level       
II-III 1.00 1.00 1.00 1.00 1.00 1.00
IV-V 3.75 (2.11-6.69) 6.28 (2.65-14.89) 2.37 (1.07-5.22) 0.52 (0.26-1.03) 1.04 (0.32-3.43) 0.36 (0.12-1.07)
Ulceration       
No 1.00 1.00 1.00 1.00 1.00 1.00
Yes 5.82 (3.13-10.80) 5.90 (2.41-14.42) 7.21 (2.97-17.48) 1.56 (0.65-3.76) 0.70 (0.23-2.12) 5.46 (1.70-17.53)
Clinical stage       
1 1.00 1.00 1.00 1.00 1.00 1.00
2-4 15.02 (16.39-35.30) 25.41 (5.81-111.08) 11.76 (3.86-35.87) 5.56 (3.02-24.28) 6.88 (1.64-28.89) 6.39 (1.56-26.25)
Vascular invasion       
No 1.00 1.00 1.00 1.00 1.00 1.00
Yes 9.25 (3.56-17.79) 20.48 (5.47-76.65) 6.87 (2.96-15.97) 3.44 (1.63-7.25) 4.79 (1.21-19.01) 11.15 (3.42-36.38)
Mitotic count       
0/mm2 1.00 1.00 1.00 1.00 1.00 1.00
> = 1/mm2 7.95 (3.56-17.80) 27.24 (3.65-203.10) 4.83 (1.92-12.13) 3.28 (1.11-9.73) 6.87 (0.77-61.05) 2.21 (0.53-9.13)
Lymphocytic infiltrate       
None-mild 1.00 1.00 1.00 1.00 1.00 1.00
Moderate-brisk 0.43 (0.24-0.78) 0.45 (1.19-1.08) 0.43 (0.19-0.94) 0.73 (0.37-1.44) 0.87 (0.31-2.43) 0.69 (0.25-1.90)
Ki67 expression       
0-25% 1.00 1.00 1.00 1.00 1.00 1.00
>25% 2.46 (1.33-4.56) 1.67 (0.67-4.15) 4.06 (1.74-9.48) 1.74 (0.85-3.54) 0.96 (0.24-3.78) 6.14 (1.76-21.39)
  1. LMM = lentigo maligna melanoma, SSM = superficial spreading melanoma, NMM = nodular malignant melanoma.
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Biology of Sex Differences

ISSN: 2042-6410

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