Disease free survival
|
Univariable
|
Multivariable
|
---|
All HR(95%CI)
|
Women HR(95%CI)
|
Men HR(95%CI)
|
All HR(95%CI)
|
Women HR(95%CI)
|
Men HR(95%CI)
|
---|
Age
| | | | | | |
Continuous
|
1.01 (0.97-1.05)
|
1.00 (0.95-1.05)
|
1.01 (0.95-1.07)
|
0.98 (0.94-1.02)
|
1.00 (0.94-1.06)
|
1.00 (0.92-1.09)
|
Sex
| | | | | | |
Women
|
1.00
|
-
|
-
|
1.00
|
-
|
-
|
Men
|
1.51 (0.85-2.70)
|
-
|
-
|
1.06 (0.52-2.15)
|
-
|
-
|
Histological subtype
| | | | | | |
LMM + SSM
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
NMM
|
5.63 (3.15-10.08)
|
6.36 (2.67-15.12)
|
5.39 (2.41-12.09)
|
1.21 (0.55-2.63)
|
1.47 (0.48-4.54)
|
1.49 (0.46-4.82)
|
Breslow thickness
| | | | | | |
<=1 mm
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
> 1 mm
|
8.44 (4.27-16.68)
|
12.17 (4.07-36.34)
|
6.12 (2.14-14.73
|
0.61 (0.10-3.70)
|
0.17 (0.01-2.95)
|
1.45 (0.15-14.22)
|
Clark level
| | | | | | |
II-III
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
IV-V
|
3.75 (2.11-6.69)
|
6.28 (2.65-14.89)
|
2.37 (1.07-5.22)
|
0.52 (0.26-1.03)
|
1.04 (0.32-3.43)
|
0.36 (0.12-1.07)
|
Ulceration
| | | | | | |
No
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
Yes
|
5.82 (3.13-10.80)
|
5.90 (2.41-14.42)
|
7.21 (2.97-17.48)
|
1.56 (0.65-3.76)
|
0.70 (0.23-2.12)
|
5.46 (1.70-17.53)
|
Clinical stage
| | | | | | |
1
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
2-4
|
15.02 (16.39-35.30)
|
25.41 (5.81-111.08)
|
11.76 (3.86-35.87)
|
5.56 (3.02-24.28)
|
6.88 (1.64-28.89)
|
6.39 (1.56-26.25)
|
Vascular invasion
| | | | | | |
No
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
Yes
|
9.25 (3.56-17.79)
|
20.48 (5.47-76.65)
|
6.87 (2.96-15.97)
|
3.44 (1.63-7.25)
|
4.79 (1.21-19.01)
|
11.15 (3.42-36.38)
|
Mitotic count
| | | | | | |
0/mm2
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
> = 1/mm2
|
7.95 (3.56-17.80)
|
27.24 (3.65-203.10)
|
4.83 (1.92-12.13)
|
3.28 (1.11-9.73)
|
6.87 (0.77-61.05)
|
2.21 (0.53-9.13)
|
Lymphocytic infiltrate
| | | | | | |
None-mild
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
Moderate-brisk
|
0.43 (0.24-0.78)
|
0.45 (1.19-1.08)
|
0.43 (0.19-0.94)
|
0.73 (0.37-1.44)
|
0.87 (0.31-2.43)
|
0.69 (0.25-1.90)
|
Ki67 expression
| | | | | | |
0-25%
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
>25%
|
2.46 (1.33-4.56)
|
1.67 (0.67-4.15)
|
4.06 (1.74-9.48)
|
1.74 (0.85-3.54)
|
0.96 (0.24-3.78)
|
6.14 (1.76-21.39)
|
- LMM = lentigo maligna melanoma, SSM = superficial spreading melanoma, NMM = nodular malignant melanoma.