Disease free survival | Univariable | Multivariable | ||||
---|---|---|---|---|---|---|
All HR(95%CI) | Women HR(95%CI) | Men HR(95%CI) | All HR(95%CI) | Women HR(95%CI) | Men HR(95%CI) | |
Age | ||||||
Continuous | 1.01 (0.97-1.05) | 1.00 (0.95-1.05) | 1.01 (0.95-1.07) | 0.98 (0.94-1.02) | 1.00 (0.94-1.06) | 1.00 (0.92-1.09) |
Sex | ||||||
Women | 1.00 | - | - | 1.00 | - | - |
Men | 1.51 (0.85-2.70) | - | - | 1.06 (0.52-2.15) | - | - |
Histological subtype | ||||||
LMM + SSM | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
NMM | 5.63 (3.15-10.08) | 6.36 (2.67-15.12) | 5.39 (2.41-12.09) | 1.21 (0.55-2.63) | 1.47 (0.48-4.54) | 1.49 (0.46-4.82) |
Breslow thickness | ||||||
<=1 mm | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
> 1 mm | 8.44 (4.27-16.68) | 12.17 (4.07-36.34) | 6.12 (2.14-14.73 | 0.61 (0.10-3.70) | 0.17 (0.01-2.95) | 1.45 (0.15-14.22) |
Clark level | ||||||
II-III | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
IV-V | 3.75 (2.11-6.69) | 6.28 (2.65-14.89) | 2.37 (1.07-5.22) | 0.52 (0.26-1.03) | 1.04 (0.32-3.43) | 0.36 (0.12-1.07) |
Ulceration | ||||||
No | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
Yes | 5.82 (3.13-10.80) | 5.90 (2.41-14.42) | 7.21 (2.97-17.48) | 1.56 (0.65-3.76) | 0.70 (0.23-2.12) | 5.46 (1.70-17.53) |
Clinical stage | ||||||
1 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
2-4 | 15.02 (16.39-35.30) | 25.41 (5.81-111.08) | 11.76 (3.86-35.87) | 5.56 (3.02-24.28) | 6.88 (1.64-28.89) | 6.39 (1.56-26.25) |
Vascular invasion | ||||||
No | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
Yes | 9.25 (3.56-17.79) | 20.48 (5.47-76.65) | 6.87 (2.96-15.97) | 3.44 (1.63-7.25) | 4.79 (1.21-19.01) | 11.15 (3.42-36.38) |
Mitotic count | ||||||
0/mm2 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
> = 1/mm2 | 7.95 (3.56-17.80) | 27.24 (3.65-203.10) | 4.83 (1.92-12.13) | 3.28 (1.11-9.73) | 6.87 (0.77-61.05) | 2.21 (0.53-9.13) |
Lymphocytic infiltrate | ||||||
None-mild | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
Moderate-brisk | 0.43 (0.24-0.78) | 0.45 (1.19-1.08) | 0.43 (0.19-0.94) | 0.73 (0.37-1.44) | 0.87 (0.31-2.43) | 0.69 (0.25-1.90) |
Ki67 expression | ||||||
0-25% | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
>25% | 2.46 (1.33-4.56) | 1.67 (0.67-4.15) | 4.06 (1.74-9.48) | 1.74 (0.85-3.54) | 0.96 (0.24-3.78) | 6.14 (1.76-21.39) |