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Table 5 Plasma follistatin and myostatin concentrations and muscle myoD, myostatin, and follistatin gene expression in young and old men and women

From: Sexually dimorphic effect of aging on skeletal muscle protein synthesis

  MEN WOMEN ANOVA
  Young Old Young Old Sex Age Interaction
Plasma (ng/mL)
Myostatin 3.12 ± 0.30 3.36 ± 0.24 3.29 ± 0.34 3.54 ± 0.42 0.61 0.47 0.99
Follistatin 1.58 ± 0.12 1.87 ± 0.12 1.22 ± 0.08 1.81 ± 0.12 0.07 0.005 0.19
Muscle mRNA (arbitrary units)
Myostatin 1.00 ± 0.28 0.73 ± 0.17 0.82 ± 0.12 0.95 ± 0.17 0.92 0.70 0.28
Follistatin 1.00 ± 0.32 0.68 ± 0.19 1.40 ± 0.46 1.55 ± 0.59 0.15 0.85 0.58
MyoD 1.00 ± 0.39 1.21 ± 0.21 1.26 ± 0.38 1.12 ± 0.28 0.68 0.97 0.68
  1. Values are means ± SEM. Muscle mRNA data were obtained from muscle biopsies collected during basal conditions.