Sexually dimorphic effect of aging on skeletal muscle protein synthesis

Smith, Gordon I; Reeds, Dominic N; Hall, Angela M; Chambers, Kari T; Finck, Brian N; Mittendorfer, Bettina

doi:10.1186/2042-6410-3-11

Biology of Sex Differences

Table 4 Plasma phenylalanine concentrations and enrichments and muscle free and protein-bound phenylalanine enrichments during basal, postabsorptive conditions and during the hyperinsulinemic-hyperaminoacidemic clamp in young and old women

From: Sexually dimorphic effect of aging on skeletal muscle protein synthesis

Time (min)	Concentration		Enrichment
	(μM)		Muscle protein bound TTR		Muscle free TTR		Plasma TTR
	*Young*	*Old*	*Young*	*Old*	*Young*	*Old*	*Young*	*Old*
Basal conditions
60	63 ± 3	60 ± 3	0.000057 ± 0.000015	0.000062 ± 0.000017	0.0602 ± 0.0032	0.0622 ± 0.0052	0.0906 ± 0.0038	0.0862 ± 0.0027
90	64 ± 6	61 ± 2	---	---	---	---	0.0986 ± 0.0048	0.0893 ± 0.0039
120	56 ± 3	54 ± 2	---	---	---	---	0.1009 ± 0.0015	0.0952 ± 0.0040
150	56 ± 5	64 ± 3	---	---	---	---	0.0998 ± 0.0031	0.0967 ± 0.0043
180	59 ± 2	60 ± 4	---	---	---	---	0.1038 ± 0.0034	0.1013 ± 0.0038
210	63 ± 3	62 ± 4	---	---	---	---	0.1041 ± 0.0029	0.1020 ± 0.0043
240	66 ± 2	65 ± 4	0.000147 ± 0.000015	0.000176 ± 0.000020	0.0722 ± 0.0040	0.0673 ± 0.0045	0.1023 ± 0.0024	0.1026 ± 0.0039
Δ (240 – 60 min)			0.000090 ± 0.000014	0.000114 ± 0.000012
Mean	61 ± 3	61 ± 3			0.0662 ± 0.0035	0.0648 ± 0.0044	0.1000 ± 0.0027	0.0962 ± 0.0035
Hyperinsulinemic-hyperaminoacidemic clamp
270	111 ± 10	92 ± 4	---	---	---	---	0.1027 ± 0.0045	0.1013 ± 0.0086
300	108 ± 8	111 ± 7	---	---	---	---	0.0950 ± 0.0024	0.1026 ± 0.0065
330	122 ± 16	106 ± 7	---	---	---	---	0.0926 ± 0.0020	0.0894 ± 0.0069
360	124 ± 14	122 ± 9	---	---	---	---	0.0944 ± 0.0032	0.0922 ± 0.0035
390	128 ± 11	109 ± 5	---	---	---	---	0.0970 ± 0.0029	0.0838 ± 0.0063
420	120 ± 5	114 ± 3	0.000305 ± 0.000020	0.000348 ± 0.000027	0.0752 ± 0.0019	0.0782 ± 0.0033	0.0971 ± 0.0026	0.0929 ± 0.0038
Δ (420 – 240 min)			0.000157 ± 0.000016	0.000171 ± 0.000017
Mean	119 ± 10	109 ± 4			0.0737 ± 0.0028	0.0727 ± 0.0034	0.0965 ± 0.0024	0.0937 ± 0.0046

Values are means ± SEM.

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ISSN: 2042-6410

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