Effects of a selectively bred novelty-seeking phenotype on the motivation to take cocaine in male and female rats

Table 1 Change in the number of active nose pokes per minute between the first drug-available and no-drug sessions expressed as percentage changes from the drug-available session^a

Rat type	Day 1	Day 2	Day 3	Day 4
bHR male	112.82 (33.0)	131.70 (33.3)	109.43 (46.5)	83.08 (46.4)
bHR female	72.17 (24.2)	59.54 (16.6)	60.77 (9.24)	82.00 (34.8)
bLR male	46.30 (24.5)	87.53 (10.3)	100.98 (46.7)	83.62 (51.8)
bLR female	290.85 (102.0)^b,c,d	142.93 (37.5)^c	88.03 (33.1)^e	21.39 (5.0)^e

^abHR, bred High Responder; bLR, bred Low Responder; data are expressed as means ± SEM; ^b P < 0.05, effect of sex within phenotype for that day; ^c P < 0.05, significantly different from 100%, P < 0.05; ^d P < 0.05, effect of phenotype within sex for that day; ^e P < 0.05, significantly different from Day 1.

ISSN: 2042-6410