Skip to main content

Articles

Page 1 of 14

  1. Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults, with limited treatment modalities and poor prognosis. Recent studies have highlighted the importance of considering sex differenc...

    Authors: Byunghyun Jang, Dayoung Yoon, Ji Yoon Lee, Jiwon Kim, Jisoo Hong, Harim Koo and Jason K. Sa
    Citation: Biology of Sex Differences 2024 15:23
  2. There is an ongoing debate on whether sex affects immune-suppressive tumor microenvironment and immunotherapy. Here, we explored the underlying molecular bases for sex dimorphisms and their impact on the effic...

    Authors: Huimeng Yan, Jinyuan Huang, Yingying Li and Bin Zhao
    Citation: Biology of Sex Differences 2024 15:22
  3. Differences in male vs. female immune responses are well-documented and have significant clinical implications. While the immunomodulatory effects of sex hormones are well established, the contributions of sex...

    Authors: Carly J. Amato-Menker, Quinn Hopen, Andrea Pettit, Jasleen Gandhi, Gangqing Hu, Rosana Schafer and Jennifer Franko
    Citation: Biology of Sex Differences 2024 15:21
  4. Following exposure to traumatic stress, women are twice as likely as men to develop mood disorders. Yet, individual responses to such stress vary, with some people developing stress-induced psychopathologies w...

    Authors: Arax Tanelian, Bistra Nankova, Mariam Miari and Esther L. Sabban
    Citation: Biology of Sex Differences 2024 15:20
  5. Sex differences exist in the risk of developing type 1 and type 2 diabetes, and in the risk of developing diabetes-associated complications. Sex differences in glucose homeostasis, islet and β cell biology, an...

    Authors: Celena M. Cherian, Hayley R. Reeves, Duneesha De Silva, Serena Tsao, Katie E. Marshall and Elizabeth J. Rideout
    Citation: Biology of Sex Differences 2024 15:19
  6. Pup-dam ultrasonic vocalizations (USVs) are essential to cognitive and socio-emotional development. In autism and Fragile X Syndrome (FXS), disruptions in pup-dam USV communication hint at a possible connectio...

    Authors: Gabriele Giua, Daniela Iezzi, Alba Caceres-Rodriguez, Benjamin Strauss, Pascale Chavis and Olivier J. Manzoni
    Citation: Biology of Sex Differences 2024 15:18
  7. Sex is an important factor in the progression and treatment of alcohol addiction, and therapeutic approaches may have to be tailored to potential sex differences. This highlights the importance of understandin...

    Authors: Sanne Toivainen, Li Xu, Francesco Gobbo, Andrea Della Valle, Andrea Coppola, Markus Heilig and Esi Domi
    Citation: Biology of Sex Differences 2024 15:17
  8. Major depressive disorder (MDD) is a recurring affective disorder that is two times more prevalent in females than males. Evidence supports immune system dysfunction as a major contributing factor to MDD, nota...

    Authors: Ryan T. McCallum, Rachel-Karson Thériault, Joshua D. Manduca, Isaac S. B. Russell, Angel M. Culmer, Janan Shoja Doost, Tami A. Martino and Melissa L. Perreault
    Citation: Biology of Sex Differences 2024 15:16
  9. Men and women are known to show differences in the incidence and clinical manifestations of mood and anxiety disorders. Many imaging studies have investigated the neural correlates of sex differences in emotio...

    Authors: Shefali Chaudhary, Hak Kei Wong, Yu Chen, Sheng Zhang and Chiang-Shan R. Li
    Citation: Biology of Sex Differences 2024 15:15
  10. The incidence of Alzheimer's disease (AD)—the most frequent cause of dementia—is expected to increase as life expectancies rise across the globe. While sex-based differences in AD have previously been describe...

    Authors: Jaime Llera-Oyola, Héctor Carceller, Zoraida Andreu, Marta R. Hidalgo, Irene Soler-Sáez, Fernando Gordillo, Borja Gómez-Cabañes, Beatriz Roson, Maria de la Iglesia-Vayá, Roberta Mancuso, Franca R. Guerini, Akiko Mizokami and Francisco García-García
    Citation: Biology of Sex Differences 2024 15:13
  11. Patients with depression, especially women, are associated with low bone mineral density (BMD). Traditional antidepressants are associated with negative effects on BMD. Few studies have examined the effect of ...

    Authors: Xiaofeng Lan, Haiyan Liu, Chengyu Wang, Weicheng Li, Fan Zhang, Zhibo Hu, Xiaoyu Chen, Zerui You, Yuping Ning and Yanling Zhou
    Citation: Biology of Sex Differences 2024 15:12
  12. Ex vivo lung perfusion (EVLP) is a useful tool for assessing lung grafts quality before transplantation. Studies indicate that donor sex is as an important factor for transplant outcome, as females present hig...

    Authors: Fernanda Yamamoto Ricardo-da-Silva, Roberto Armstrong-Jr, Mayara Munhoz de Assis Ramos, Marina Vidal-dos-Santos, Cristiano Jesus Correia, Petra J. Ottens, Luiz Felipe Pinho Moreira, Henri G. D. Leuvenink and Ana Cristina Breithaupt-Faloppa
    Citation: Biology of Sex Differences 2024 15:11
  13. Alcohol use disorder (AUD) is one of the most common psychiatric disorders, with the consumption of alcohol considered a leading cause of preventable deaths worldwide. Lipids play a crucial functional role in ...

    Authors: Carla Perpiñá-Clérigues, Susana Mellado, Cristina Galiana-Roselló, María Fernández-Regueras, Miguel Marcos, Francisco García-García and María Pascual
    Citation: Biology of Sex Differences 2024 15:10
  14. Androgens are important sex hormones in both men and women and are supplemented when endogenous levels are low, for gender transitioning, or to increase libido. Androgens also circulate at higher levels in wom...

    Authors: Alec C. Horton, Mary M. Wilkinson, Isabella Kilanowski-Doroh, Zhejun Dong, Jiao Liu, Benard O. Ogola, Bruna Visniauskas and Sarah H. Lindsey
    Citation: Biology of Sex Differences 2024 15:9
  15. Lewy body dementia (LBD) phenotype is associated with the presence and degree of Lewy body, Alzheimer’s pathologies, and substantia nigra neuron loss. Nigral neuron loss is associated with parkinsonism in LBD,...

    Authors: Ece Bayram, David G. Coughlin, Ravi Rajmohan and Irene Litvan
    Citation: Biology of Sex Differences 2024 15:8
  16. Cardiovascular diseases (CVD), including coronary heart disease (CHD), display a higher prevalence in men than women. This study aims to evaluate the variations in the intestinal microbiota between men and wom...

    Authors: Helena Garcia-Fernandez, Antonio P. Arenas-de Larriva, Javier Lopez-Moreno, Francisco M. Gutierrez-Mariscal, Juan L. Romero-Cabrera, Helena Molina-Abril, Jose D. Torres-Peña, Diego Rodriguez-Cano, Maria M. Malagon, Jose M. Ordovas, Javier Delgado-Lista, Pablo Perez-Martinez, Jose Lopez-Miranda and Antonio Camargo
    Citation: Biology of Sex Differences 2024 15:7
  17. Patients with anorexia nervosa (AN) often present sleep disorders and circadian hormonal dysregulation. The role of the microbiota–gut–brain axis in the regulation of feeding behavior has emerged during the la...

    Authors: Colin Salaün, Marine Courvalet, Léna Rousseau, Kévin Cailleux, Jonathan Breton, Christine Bôle-Feysot, Charlène Guérin, Marion Huré, Alexis Goichon, Jean-Claude do Rego, Pierre Déchelotte, David Ribet, Najate Achamrah and Moïse Coëffier
    Citation: Biology of Sex Differences 2024 15:6
  18. Recent decades have seen an exponential rise in global obesity prevalence, with rates nearly doubling in a span of 40 years. A comprehensive knowledge base regarding the systemic effects of obesity is required...

    Authors: Saluda Stapleton, Grace Welch, Lindsay DiBerardo and Linnea R Freeman
    Citation: Biology of Sex Differences 2024 15:5
  19. Cholesterol (Cho) is an essential lipophilic molecule in cells; however, both its decrease and its increase may favor the development of neurological diseases such as Alzheimer’s disease (AD). Although copper ...

    Authors: Marlene Zubillaga, Julia Tau, Diana Rosa, M. José Bellini and Nathalie Arnal
    Citation: Biology of Sex Differences 2024 15:4
  20. Sexually polymorphic cognition (SPC) results from the interaction between biological (birth-assigned sex (BAS), sex hormones) and socio-cultural (gender identity, gender roles, sexual orientation) factors. The...

    Authors: Louis Cartier, Mina Guérin, Fanny Saulnier, Ioana Cotocea, Amine Mohammedi, Fadila Moussaoui, Sarah Kheloui and Robert-Paul Juster
    Citation: Biology of Sex Differences 2024 15:3
  21. The placenta is vital for fetal development and its contributions to various developmental issues, such as pregnancy complications, fetal growth restriction, and maternal exposure, have been extensively studie...

    Authors: Lisa-Marie Legault, Mélanie Breton-Larrivée, Alexandra Langford-Avelar, Anthony Lemieux and Serge McGraw
    Citation: Biology of Sex Differences 2024 15:2
  22. Neonatal hypoxia ischemia (HI) related brain injury is one of the major causes of life-long neurological morbidities that result in learning and memory impairments. Evidence suggests that male neonates are mor...

    Authors: Vishal Chanana, Margaret Hackett, Nazli Deveci, Nur Aycan, Burak Ozaydin, Nur Sena Cagatay, Damla Hanalioglu, Douglas B. Kintner, Karson Corcoran, Sefer Yapici, Furkan Camci, Jens Eickhoff, Karyn M. Frick, Peter Ferrazzano, Jon E. Levine and Pelin Cengiz
    Citation: Biology of Sex Differences 2024 15:1
  23. Sex differences in language-related abilities have been reported. It is generally assumed that these differences stem from a different organization of language in the brains of females and males. However, rese...

    Authors: Carla Sanchis-Segura, Rand R. Wilcox, Alvaro Javier Cruz-Gómez, Sonia Félix-Esbrí, Alba Sebastián-Tirado and Cristina Forn
    Citation: Biology of Sex Differences 2023 14:90
  24. ESR2, a nuclear estrogen receptor also known as estrogen receptor β, is expressed in the brain and contributes to the actions of estrogen in various physiological phenomena. However, its expression profiles in...

    Authors: Masahiro Morishita, Shimpei Higo, Kinuyo Iwata and Hirotaka Ishii
    Citation: Biology of Sex Differences 2023 14:89
  25. Over the past several decades, substantial ground has been gained in understanding the biology of sex differences. With new mandates to include sex as a biological variable in NIH-funded research, greater know...

    Authors: Meredith L. Johnson, Joshua D. Preston, Cetewayo S. Rashid, Kevin J. Pearson and J. Nina Ham
    Citation: Biology of Sex Differences 2023 14:88
  26. The nucleus accumbens (NAc) is an important region in motivation and reward. Glutamatergic inputs from the infralimbic cortex (ILC) to the shell region of the NAc (NAcSh) have been implicated in driving the mo...

    Authors: Caroline S. Johnson, Andrew D. Chapp, Erin B. Lind, Mark J. Thomas and Paul G. Mermelstein
    Citation: Biology of Sex Differences 2023 14:87
  27. Celiac disease (CeD) is an immune-mediated disorder that develops in genetically predisposed individuals upon gluten consumption. HLA risk alleles explain 40% of the genetic component of CeD, so there have bee...

    Authors: Alba Hernangomez-Laderas, Ariadna Cilleros-Portet, Silvia Martínez Velasco, Sergi Marí, María Legarda, Bárbara Paola González-García, Carlos Tutau, Iraia García-Santisteban, Iñaki Irastorza, Nora Fernandez-Jimenez and Jose Ramon Bilbao
    Citation: Biology of Sex Differences 2023 14:86
  28. Metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in Western countries, evolving into metabolic dysfunction-associated steatohepatitis (MASH) with a sexual dimorphism. Fertile women...

    Authors: Carlos Cuño-Gómiz, Estefanía de Gregorio, Anna Tutusaus, Patricia Rider, Nuria Andrés-Sánchez, Anna Colell, Albert Morales and Montserrat Marí
    Citation: Biology of Sex Differences 2023 14:85
  29. Binge alcohol drinking is a risk factor linked to numerous disease states including alcohol use disorder (AUD). While men binge drink more alcohol than women, this demographic gap is quickly shrinking, and pre...

    Authors: Jean K. Rivera-Irizarry, Lia J. Zallar, Olivia B. Levine, Mary Jane Skelly, Jared E. Boyce, Thaddeus Barney, Ruth Kopyto and Kristen E. Pleil
    Citation: Biology of Sex Differences 2023 14:83
  30. Authors: Lauryn Keeler Bruce, Patrick Kasl, Severine Soltani, Varun K. Viswanath, Wendy Hartogensis, Stephan Dilchert, Frederick M. Hecht, Anoushka Chowdhary, Claudine Anglo, Leena Pandya, Subhasis Dasgupta, Ilkay Altintas, Amarnath Gupta, Ashley E. Mason and Benjamin L. Smarr
    Citation: Biology of Sex Differences 2023 14:82

    The original article was published in Biology of Sex Differences 2023 14:76

  31. Gestational sleep apnea is a hypoxic sleep disorder that affects 8–26% of pregnancies and increases the risk for central nervous system dysfunction in offspring. Specifically, there are sex differences in the ...

    Authors: Steve Mabry, E. Nicole Wilson, Jessica L. Bradshaw, Jennifer J. Gardner, Oluwadarasimi Fadeyibi, Edward Vera Jr., Oluwatobiloba Osikoya, Spencer C. Cushen, Dimitrios Karamichos, Styliani Goulopoulou and Rebecca L. Cunningham
    Citation: Biology of Sex Differences 2023 14:81
  32. Sex differences have been observed in several brain regions for the molecular mechanisms involved in baseline (resting) and memory-related processes. The ubiquitin proteasome system (UPS) is a major protein de...

    Authors: Kayla Farrell, Aubrey Auerbach, Catherine Liu, Kiley Martin, Myasia Pareno, W. Keith Ray, Richard F. Helm, Fernando Biase and Timothy J. Jarome
    Citation: Biology of Sex Differences 2023 14:80
  33. The gut microbiome has been linked to many diseases with sex bias including autoimmune, metabolic, neurological, and reproductive disorders. While numerous studies report sex differences in fecal microbial com...

    Authors: Laura Sisk-Hackworth, Jada Brown, Lillian Sau, Andrew A. Levine, Lai Ying Ivy Tam, Aishwarya Ramesh, Reeya S. Shah, Evelyn T. Kelley-Thackray, Sophia Wang, Anita Nguyen, Scott T. Kelley and Varykina G. Thackray
    Citation: Biology of Sex Differences 2023 14:79
  34. Transcranial direct current stimulation (tDCS) can influence brain network activity and associated cognitive and behavioural functions. In addition to the extensive variety in stimulation parameters, numerous ...

    Authors: Simone Weller, Birgit Derntl and Christian Plewnia
    Citation: Biology of Sex Differences 2023 14:78
  35. The prairie vole (Microtus ochrogaster) is a socially monogamous rodent that establishes an enduring pair bond after cohabitation, with (6 h) or without (24 h) mating. Previously, we reported that social interact...

    Authors: Daniela Ávila-González, Italo Romero-Morales, Lizette Caro, Alejandro Martínez-Juárez, Larry J. Young, Francisco Camacho-Barrios, Omar Martínez-Alarcón, Analía E. Castro, Raúl G. Paredes, Néstor F. Díaz and Wendy Portillo
    Citation: Biology of Sex Differences 2023 14:77
  36. Females have been historically excluded from biomedical research due in part to the documented presumption that results with male subjects will generalize effectively to females. This has been justified in par...

    Authors: Lauryn Keeler Bruce, Patrick Kasl, Severine Soltani, Varun K. Viswanath, Wendy Hartogensis, Stephan Dilchert, Frederick M. Hecht, Anoushka Chowdhary, Claudine Anglo, Leena Pandya, Subhasis Dasgupta, Ilkay Altintas, Amarnath Gupta, Ashley E. Mason and Benjamin L. Smarr
    Citation: Biology of Sex Differences 2023 14:76

    The Correction to this article has been published in Biology of Sex Differences 2023 14:82

  37. Despite observed sex differences in the prevalence of stress-related psychiatric conditions, most preclinical and translational studies have only included male subjects. Therefore, it has not been possible to ...

    Authors: Alison Wakeford, Jonathon A. Nye, Zachary A. Grieb, Dené A. Voisin, Jiyoung Mun, Kim L. Huhman, Elliott Albers and Vasiliki Michopoulos
    Citation: Biology of Sex Differences 2023 14:75
  38. Ketamine has been recently approved to treat resistant depression; however preclinical studies showed sex differences in its efficacy. Sex steroids, such as estrogens and testosterone, both in the periphery an...

    Authors: Sandra Ledesma-Corvi, Jordi Jornet-Plaza and M. Julia García-Fuster
    Citation: Biology of Sex Differences 2023 14:73
  39. Aortic stenosis (AS) is characterized by inflammation, fibrosis, osteogenesis and angiogenesis. Men and women develop these mechanisms differently. Galectin-3 (Gal-3) is a pro-inflammatory and pro-osteogenic l...

    Authors: Lara Matilla, Ernesto Martín-Núñez, Mattie Garaikoetxea, Adela Navarro, Ibai Tamayo, Amaya Fernández-Celis, Alicia Gainza, Joaquín Fernández-Irigoyen, Enrique Santamaría, Pieter Muntendam, Virginia Álvarez, Rafael Sádaba, Eva Jover and Natalia López-Andrés
    Citation: Biology of Sex Differences 2023 14:72
  40. The supraoptic nucleus (SON) of the hypothalamus contains magnocellular neurosecretory cells that secrete the hormones vasopressin and oxytocin. Sex differences in SON gene expression have been relatively unex...

    Authors: Dianna H. Nguyen, Victor Duque, Nicole Phillips, André Souza Mecawi and J. Thomas Cunningham
    Citation: Biology of Sex Differences 2023 14:71
  41. Current understanding of sodium (Na+) handling is based on studies done primarily in males. Contrary to the gradual increase in high salt (HS) induced natriuresis over 3–5 days in males, female Sprague Dawley (SD...

    Authors: Victoria L. Nasci, Rawan N. Almutlaq, David M. Pollock and Eman Y. Gohar
    Citation: Biology of Sex Differences 2023 14:70
  42. Adipose insulin resistance (Adipo-IR) is associated with multiple metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). The study aimed to evaluate sex differences in the association between...

    Authors: Ying Wei, Jia Liu, Guang Wang and Ying Wang
    Citation: Biology of Sex Differences 2023 14:69
  43. To examine the expression characteristics of single nucleotide polymorphisms (SNPs) in the SRD5A2 gene and investigate their potential association with differences in the clinical characteristics between sexes in...

    Authors: Honglei Duan, Xu Wang, Wenqian Qi, Jingyi Shi, Liang Han, Guohua Wang, Yanhui Xu, Jia Liu and Jiangbin Wang
    Citation: Biology of Sex Differences 2023 14:68
  44. The induction of electroconvulsive seizures (ECS) in rodents induces sex- and age-specific disparities in antidepressant-like responses, with females and young age being the most unresponsive ones. Since the e...

    Authors: Sandra Ledesma-Corvi and M. Julia García-Fuster
    Citation: Biology of Sex Differences 2023 14:67
  45. We have previously reported that maternal obesity reduces placental transport capacity for lysophosphatidylcholine-docosahexaenoic acid (LPC-DHA), a preferred form for transfer of DHA (omega 3) to the fetal br...

    Authors: Theresa L. Powell, Charis Uhlson, Lana Madi, Karin Zemski Berry, Stephanie S. Chassen, Thomas Jansson and Veronique Ferchaud-Roucher
    Citation: Biology of Sex Differences 2023 14:66
  46. In addition to social and cultural factors, sex differences in the central nervous system have a critical influence on behavior, although the neurobiology underlying these differences remains unclear. Interest...

    Authors: Patricia Mariscal, Lidia Bravo, Meritxell Llorca-Torralba, Jone Razquin, Cristina Miguelez, Irene Suárez-Pereira and Esther Berrocoso
    Citation: Biology of Sex Differences 2023 14:64
  47. Sex differences have been observed in the development of obesity-related complications in patients, as well as in animal models. Accumulating evidence suggests that sex-dependent regulation of lipid metabolism...

    Authors: Florian Juszczak, Louise Pierre, Morgane Decarnoncle, Inès Jadot, Blanche Martin, Olivia Botton, Nathalie Caron, Jonas Dehairs, Johannes V. Swinnen and Anne-Emilie Declèves
    Citation: Biology of Sex Differences 2023 14:63