Fig. 4
From: Treating sex and gender differences as a continuous variable can improve precision cancer treatments
Mid-range TI values exhibit distinct pathway signatures relative to the sex and gender – defined poles. (A) (Left Panel) Heatmap of pathway activation signatures underlying changes in midrange TI values for female adult cancers relative to their pole. (Right Panel) Heatmap of pathway activation signatures underlying changes in midrange TI values for male adult cancers relative their pole. (B) (Left Panel) Heatmap of pathway activation signatures underlying changes in midrange TI values for pediatric female cancers relative to their pole. (Right Panel) Heatmap of pathway activation signatures underlying changes in midrange TI values for pediatric male cancers relative their pole. For all panels, changes in male (blue circles) and female (red circles) signatures are indicated. Gene counts (count) are symbolized by the size of the circles and False Discovery Rates (FDR) by the saturation of the fill as indicated in the legends. Only cancer types and pathways with significant change are shown