Fig. 5

Experimental design (A) and auxological parameters of body (B), femur (C) and tibia (D) length in Pappa2^ko/ko and Pappa2^wt/wt mice (males and females) treated with rhGH, rhIGF1 and rhPAPP-A2 for 30 days, from PND5 to PND35. Data are represented as mean ± S.E.M (N = 8–10 per experimental group). Two-way ANOVA and Tukey-corrected tests: */**/***p < 0.05/0.01/0.001 versus respective saline-treated males and females; ^#/##/###p < 0.05/0.01/0.001 versus respective wt/wt males and females