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Table 3 Features of people who did not have a dementia diagnosis at baseline and were diagnosed with dementia during follow-up

From: Sex differences for clinical correlates of substantia nigra neuron loss in people with Lewy body pathology

 

Females (n = 40)

Males (n = 58)

p value

Clinical features at first visit with dementia

   

 Age

80.4 (8.96)

77.9 (10.6)

0.42

 Years of education

16.9 (13.5)

16.6 (3.08)

0.9

 CDR®–SOB

6.83 (5.69)

5.54 (3.76)

0.36

 NPI-Q

4.82 (5.55)

5.35 (5.04)

0.81

 Clinical diagnosis of Lewy body dementia (%)

7 (17.5%)

20 (34.5%)

0.27

  -Parkinson’s disease dementia

3 (7.5%)

7 (12.1%)

0.69

  -Dementia with Lewy bodies

4 (10.0%)

13 (22.4%)

0.27

 Clinical diagnosis of AD (%)

31 (77.5%)

42 (72.4%)

0.79

 Cognitive fluctuations (%)

7 (21.2%)

16 (30.2%)

0.59

 Visual hallucinations (%)

7 (17.9%)

11 (19.0%)

0.9

 REM sleep behavior disorder (%)

2 (5.9%)

13 (24.5%)

0.15

 Parkinsonism (%)

7 (18.4%)

26 (46.4%)

0.072

Neuropathological features

   

 Lewy body pathology stage (%)

  

0.83

  -Brainstem-predominant

2 (5.0%)

7 (12.1%)

  -Limbic (transitional)

14 (35.0%)

17 (29.3%)

  -Neocortical (diffuse)

24 (60.0%)

34 (58.6%)

 Level of substantia nigra neuron loss (%)

  

0.89

  -None

8 (20%)

9 (15.5%)

  -Mild

10 (25.0%)

17 (29.3%)

  -Moderate

13 (32.5%)

18 (31.0%)

  -Severe

9 (22.5%)

14 (24.1%)

 AD neuropathologic change (%)

  

0.27

  -None

0 (0%)

4 (6.9%)

  -Low

7 (17.5%)

4 (6.9%)

  -Intermediate

6 (15.0%)

23 (39.7%)

  -High

27 (67.5%)

27 (46.6%)

 Thal amyloid phase

4.43 (0.98)

3.79 (1.41)

0.072

 Braak tau stage

4.75 (1.69)

4.45 (1.39)

0.27

 CERAD neuritic plaque score

2.38 (1.01)

2.17 (0.94)

0.27

 Presence of ischemic, hemorrhagic or vascular pathology (%)

40 (100%)

58 (100%)

N/A

  1. All variables are reported as mean (standard deviation) or count (percentage). Group comparisons were performed using χ2, Mann–Whitney U and t tests, as appropriate. Statistical significance is bolded and marked with * for FDR-corrected p < 0.05
  2. AD Alzheimer’s disease, CDR®–SOB CDR® Dementia Staging Instrument–Sum of Boxes, NPI-Q Neuropsychiatric Inventory-Questionnaire, N/A not applicable