Fig. 5
From: Aromatase inhibition and ketamine in rats: sex-differences in antidepressant-like efficacy
Long-lasting antidepressant-like effects of ketamine or letrozole in rats. Repeated (65-day post-treatment) effects exerted by ketamine exposure in male and female rats pre-treated with vehicle or letrozole in the forced-swim test (FST). Data represent mean ± SEM of the time spent (s) immobile, climbing, or swimming. Three-way ANOVAs (independent variables: sex, pre-treatment and treatment) or two-way ANOVAs (independent variables: pre-treatment and treatment) were performed and results are shown in Additional file 1: Table S2. ###p < 0.01 and #p < 0.05 when comparing female vs. male rats (effect of Sex). Sal saline, Ket ketamine, Veh vehicle, LTZ letrozole