Fig. 5
From: Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus
Deduced regulation mechanism of ptk2β in sex differentiation by Ptk2β/EGFR/STAT3 pathway. A Expression profile of the sex related gene after ZD6474 treatment in vivo; B Schematic showing the stat3 binding sites in cyp19a1 promoter; C Luciferase assay showing the activity of deletions constructs; D Schematic showing the mutation of stat3 and the wild type; E Luciferase assay showing site mutation of promoter in 293 T cells; F Diagram illustrating the hypothetical mechanism of ptk2β during sex differentiation in M. albus by Ptk2β/EGFR/STAT3 pathway. The mean ± SEM was from three independent experiments, *P < 0.05 show significantly difference