Fig. 6
From: Endothelin mediates sex-differences in acclimation to high salt diet in rats
Dual ET receptor antagonism eliminated the sex-difference in urinary ET-1 excretion. Urinary excretion rate of ET-1 (A) and NOx (B) in male and female rats fed a NS or a HS diet. Rats were either treated with or without the dual ET receptor antagonist (A-182086, 10 mg/kg/day). N = 7–13 per group. Two-way ANOVA with post hoc Sidak’s test. P values < 0.05 from post hoc test are displayed on graph. Endothelin receptor (ET), endothelin 1 (ET-1), high salt (HS), normal salt (NS), and total nitric oxide metabolites (NOx)