Table 5 Univariate and multivariate analyses of the risk factors associated with HBV-related liver fibrosis in patients with chronic HBV infection (n = 1007)
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
OR (95%CI) | P | OR (95%CI) | P | |
Male | 1.98 (1.50, 2.61) |  < 0.001 | 1.84 (1.34, 2.54) |  < 0.001 |
Age > 50 years old | 3.41 (2.62, 4.45) |  < 0.001 | 3.61 (2.69, 4.84) |  < 0.001 |
Drinking | 1.40 (1.07, 1.85) | 0.016 | 0.95 (0.68, 1.31) | 0.735 |
HOMA-IR ≥ 2.5 | 1.34 (1.03, 1.74) | 0.027 | 1.35 (1.00, 1.82) | 0.05 |
HBeAg positive | 2.27 (1.58, 3.26) |  < 0.001 | 2.14 (1.43, 3.21) |  < 0.001 |
HBsAg load, log IU/mL | 6.20 (3.49, 11.02) |  < 0.001 | 6.32 (3.37, 11.88) |  < 0.001 |
HBV load, log IU/mL | 1.35 (1.24, 1.45) |  < 0.001 | 1.34 (1.23, 1.46) |  < 0.001 |
HBV genotype C | 1.63 (1.17, 2.25) | 0.003 | 1.63 (1.13, 2.35) | 0.008 |
SRD5A2 rs12470143 C > T | 1.88 (1.15, 3.06) | 0.011 | 1.79 (1.05, 3.05) | 0.033 |
SRD5A2 rs7594951 C > T | 3.36 (1.73, 6.53) |  < 0.001 | 4.55 (2.17, 9.54) |  < 0.001 |