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Table 4 Comparison of the genotype and allele frequencies of SRD5A2 rs12470143 and rs7594951 between different liver fibrosis stages in patients with chronic HBV infection

From: Two genetic variants in the SRD5A2 gene are found to be associated with sex differences in the disease characteristics of patients with chronic hepatitis B virus infection

Variant

F0–2, n (%)

F3–4, n (%)

χ2

P value

SRD5A2 rs12470143

Genotype

   

 CC

560 (75.6%)

165 (62.0%)

40.479

 < 0.001

 CT

153 (20.6%)

62 (23.3%)

  

 TT

28 (3.8%)

39 (14.7%)

  

Allele

    

 C

1273 (85.9%)

392 (73.7%)

78.601

 < 0.001

 T

179 (14.1%)

140 (26.3%)

  

SRD5A2 rs7594951

Genotype

   

 CC

648 (87.4%)

199 (74.8%)

58.253

 < 0.001

 CT

73 (9.9%)

25 (9.4%)

  

 TT

20 (2.7%)

42 (15.8%)

  

Allele

    

 C

1369 (92.4%)

423 (79.5%)

66.050

 < 0.001

 T

113 (7.6%)

109 (20.5%)

  
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Biology of Sex Differences

ISSN: 2042-6410

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