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Table 3 Genotype and allele frequencies of two genetic variants in the SRD5A2 gene between male and female patients with chronic HBV infection

From: Two genetic variants in the SRD5A2 gene are found to be associated with sex differences in the disease characteristics of patients with chronic hepatitis B virus infection

Variants

Male, n (%)

Female, n (%)

χ2

P value

SRD5A2 rs12470143

Genotype

   

 CC

461 (69.4%)

294 (85.7%)

44.949

 < 0.001

 CT

161 (24.2%)

24 (7.0%)

  

 TT

42 (6.3%)

25 (7.3%)

  

Allele

    

 C

1083 (81.6%)

611 (89.1%)

19.119

 < 0.001

 T

245 (18.4%)

75 (10.9%)

  

SRD5A2 rs7594951

Genotype

   

 CC

538 (81.0%)

309 (85.7%)

33.186

 < 0.001

 CT

90 (13.6%)

8 (6.7%)

  

 TT

36 (5.4%)

26 (7.6%)

  

Allele

    

 C

1166 (87.8%)

626 (91.3%)

5.497

0.019

 T

162 (12.2%)

60 (8.7%)

  
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Biology of Sex Differences

ISSN: 2042-6410

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