Two genetic variants in the SRD5A2 gene are found to be associated with sex differences in the disease characteristics of patients with chronic hepatitis B virus infection

Table 1 Demographic and clinicopathological characteristics of the patients with chronic HBV and the controls

Characteristics	Chronic HBV patients (n = 1007)	Controls (n = 1040)	P-value
Age, years	48.19 ± 11.3	49.31 ± 10.57	0.058
Male/female, %	65.9/34.1	61.6/38.4	0.024
Smoking, n (%)	224 (22.3%)	198 (19.3%)	0.080
Drinking, n (%)	291 (28.9%)	265 (25.5%)	0.091
Hypertension*, n (%)	166 (16.5%)	147 (14.1%)	0.140
Fatty liver, n (%)	194 (19.3%)	225 (21.6%)	0.184
BMI, kg/m²	24.11 (22.49, 26.70)	25.04 (22.20, 27.91)	0.118
HOMA-IR	2.33 (1.96, 2.66)	2.36 (1.96, 2.68)	0.766
ALT, IU/L	59.66 (32.97, 87.08)	27.19 (19.67, 39.39)	< 0.001
AST, IU/L	57.60 (33.00, 86.90)	26.73 (22.03, 34.82)	< 0.001
ALB, g/L	31.70 (28.70, 35.30)	37.05 (31.02, 41.81)	< 0.001
Cholinesterase, IU/L	9080 (7620, 10,460)	10,904 (9001, 13,406)	< 0.001
PLT (10⁹/L)	101 (81, 122)	186 (117.25, 250)	< 0.001
HBeAg positive, %	827 (82.1%)
HBsAg (log10IU/ml))	3.75 (3.55, 3.89)
HBV DNA (log10IU/ml)	6.3 (5.14, 7.7)
HBV genotype 2/3, %	20.5/79.5
E, kPa
F0–2	7.6 (6.75, 8.4)
F3–4	11.3 (10.1, 12.6)

Count data: n (%) indicated; measurement data conform to a normal distribution: mean ± standard deviation; measurement data do not follow a normal distribution: median (interquartile spacing). *Here and below, hypertension was defined as systolic blood pressure > 140 mmHg or diastolic blood pressure > 90 mmHg, BMI body mass index, HOMA-IR insulin resistance index, ALT glutamic aminotransferase, AST glutamic aminotransferase

ISSN: 2042-6410