Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity

Powell, Theresa L.; Uhlson, Charis; Madi, Lana; Berry, Karin Zemski; Chassen, Stephanie S.; Jansson, Thomas; Ferchaud-Roucher, Veronique

doi:10.1186/s13293-023-00548-1

Table 1 Profile of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) containing DHA and ARA in placenta of obese (n = 16) compared to normal BMI women (n = 16) regarding the fetal sex

From: Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity

	Placenta
	Female			Male
Relative level/µg prot	Ctr (n = 9)	Ob (n = 11)	p value (FDR)	Ctr (n = 7)	Ob (n = 5)	p value (FDR)
PC-DHA
PC 16:0_22:6	0.03 ± 0.02	0.01 ± 0.008	0.126	0.030 ± 0.010	0.012 ± 0.005	0.045
PC O-16:0_22:6	0.01 ± 0.01	0.006 ± 0.004	0.179	0.012 ± 0.007	0.004 ± 0.002	0.129
PC P-16:0_22:6	0.009 ± 0.007	0.004 ± 0.003	0.126	0.008 ± 0.005	0.003 ± 0.001	0.202
PC 18:0_22:6	0.02 ± 0.02	0.009 ± 0.005	0.101	0.025 ± 0.015	0.008 ± 0.003	0.039
PC 18:1_22:6	0.01 ± 0.007	0.004 ± 0.004	0.098	0.010 ± 0.006	0.005 ± 0.002	0.157
PC O-18:0_22:6	0.01 ± 0.01	0.003 ± 0.002	0.126	0.010 ± 0.008	0.003 ± 0.001	0.129
PC O-18:1_22:6	0.02 ± 0.02	0.004 ± 0.002	0.101	0.013 ± 0.010	0.003 ± 0.002	0.101
PC 20:4_22:6	0.005 ± 0.004	0.003 ± 0.002	0.284	0.003 ± 0.002	0.002 ± 0.002	0.157
LPC 22:6	0.0007 ± 0.0003	0.0004 ± 0.00008	0.098	0.001 ± 0.0001	0.0002 ± 0.00005	0.039
PC-ARA
PC 16:0_20:4	0.76 ± 0.58	0.24 ± 0.18	0.098	0.74 ± 0.49	0.06 ± 0.01	0.029
PC 16:1_20:4	0.02 ± 0.01	0.001 ± 0.001	0.101	0.02 ± 0.02	nd
PC O-16:0_20:4	0.14 ± 0.11	0.05 ± 0.02	0.101	0.13 ± 0.09	0.03 ± 0.01	0.045
PC P-16:0_20:4	0.13 ± 0.09	0.03 ± 0.02	0.098	0.12 ± 0.09	0.03 ± 0.02	0.101
PC 18:0_20:4	0.56 ± 0.46	0.17 ± 0.12	0.098	0.56 ± 0.41	0.15 ± 0.10	0.045
PC 18:1_20:4	0.21 ± 0.14	0.05 ± 0.04	0.098	0.21 ± 0.15	0.03 ± 0.03	0.039
PC 18:2_20:4	0.08 ± 0.06	0.02 ± 0.01	0.098	0.09 ± 0.05	0.005 ± 0.003	0.029
PC O-18:0_20:4	0.12 ± 0.12	0.05 ± 0.02	0.152	0.11 ± 0.08	0.06 ± 0.04	0.222
PC O-18:1_20:4	0.28 ± 0.23	0.09 ± 0.04	0.165	0.25 ± 0.18	0.11 ± 0.07	0.222
PC 20:1_20:4	0.02 ± 0.01	0.006 ± 0.003	0.101	0.01 ± 0.01	0.006 ± 0.003	0.222
PC 20:2_20:4	0.01 ± 0.009	0.005 ± 0.003	0.152	0.01 ± 0.007	0.005 ± 0.005	0.129
PC 20:3_20:4	0.03 ± 0.01	0.009 ± 0.006	0.098	0.02 ± 0.01	0.009 ± 0.005	0.280
PC 20:4_20:4	0.02 ± 0.01	0.006 ± 0.003	0.098	0.02 ± 0.01	0.003 ± 0.002	0.039
LPC 20:4	0.09 ± 0.07	0.06 ± 0.05	0.359	0.07 ± 0.06	0.04 ± 0.01	0.471
LPC
LPC 16:0	0.13 ± 0.05	0.171 ± 0.12	0.534	0.06 ± 0.03	0.14 ± 0.15	0.434
LPC 16:1	0.002 ± 0.001	0.005 ± 0.003	0.165	0.002 ± 0.0002	0.002 ± 0.001	0.825
LPC 18:0	0.09 ± 0.07	0.06 ± 0.05	0.567	0.07 ± 0.06	0.04 ± 0.01	0.471
LPC 18:1	0.02 ± 0.01	0.02 ± 0.009	0.746	0.01 ± 0.008	0.02 ± 0.02	0.646
LPC 18:2	0.01 ± 0.02	0.01 ± 0.008	0.699	0.01 ± 0.009	0.01 ± 0.01	0.471
LPC 20:3	0.01 ± 0.07	0.005 ± 0.003	0.301	0.009 ± 0.007	0.003 ± 0.002	0.210
PE-DHA
PE 16:1_22:6	0.04 ± 0.02	0.01 ± 0.006	0.034	0.03 ± 0.03	0.02 ± 0.01	0.650
PE 16:0_22:6	0.07 ± 0.03	0.03 ± 0.01	0.030	0.06 ± 0.03	0.05 ± 0.03	0.704
PE O-16:0_22:6	0.40 ± 0.28	0.14 ± 0.07	0.037	0.34 ± 0.24	0.22 ± 0.15	0.649
PE P-16:0_22:6	0.45 ± 0.29	0.14 ± 0.08	0.030	0.41 ± 0.27	0.22 ± 0.16	0.297
PE 18:0_22:6	0.19 ± 0.09	0.08 ± 0.04	0.030	0.18 ± 0.10	0.11 ± 0.08	0.274
PE O-18:0_22:6	0.10 ± 0.08	0.02 ± 0.01	0.037	0.09 ± 0.09	0.03 ± 0.02	0.560
PE P-18:0_22:6	0.31 ± 0.26	0.05 ± 0.02	0.030	0.29 ± 0.28	0.07 ± 0.05	0.234
PE 18:1_22:6	0.11 ± 0.06 (n = 4)	0.06 ± 0.03	0.133	0.10 ± 0.03 (n = 4)	0.09 ± 0.07	0.767
PE 18:2_22:6	0.03 ± 0.01	0.01 ± 0.007	0.030	0.03 ± 0.02	0.02 ± 0.01	0.369
LPE 22:6	0.005 ± 0.002	0.003 ± 0.002	0.119	0.005 ± 0.002	0.003 ± 0.002	0.283
PE-ARA
PE 16:1_20:4	0.26 ± 0.15	0.09 ± 0.04	0.037	0.21 ± 0.12	0.09 ± 0.02	0.234
PE 16:0_20:4	1.65 ± 0.95	0.98 ± 0.37	0.120	1.43 ± 0.87	0.80 ± 0.44	0.297
PE O-16:0_20:4	0.50 ± 0.27	0.23 ± 0.09	0.037	0.41 ± 0.20	0.21 ± 0.07	0.202
PE P-16:0_20:4	2.42 ± 1.43	1.11 ± 0.45	0.037	2.06 ± 1.02	0.97 ± 0.28	0.202
PE 18:0_20:4	2.26 ± 1.19	1.10 ± 0.36	0.037	2.03 ± 1.03	0.99 ± 0.34	0.202
PE O-18:0_20:4	0.66 ± 0.45	0.22 ± 0.09	0.037	0.59 ± 0.44	0.17 ± 0.04	0.202
PE P-18:0_20:4	2.95 ± 1.93	1.01 ± 0.43	0.037	2.67 ± 1.93	0.77 ± 0.17	0.195
PE 18:1_20:4	0.75 ± 0.37	0.36 ± 0.13	0.037	0.63 ± 0.27	0.32 ± 0.13	0.202
PE 18:2_20:4	0.18 ± 0.09	0.08 ± 0.03	0.037	0.16 ± 0.05	0.07 ± 0.04	0.195
PE 20:4_20:4	0.02 ± 0.009	0.02 ± 0.007	0.114	0.02 ± 0.004	0.01 ± 0.005	0.202
LPE 20:4	0.06 ± 0.08	0.01 ± 0.01	0.093	0.06 ± 0.03	0.002 ± 0.002	0.234

20:4 = ARA, 22:6 = DHA, PC = phosphatidylcholine, PE = phosphatidylethanolamine, LPC = lysophosphatidylcholine, LPE = lysophosphatidylethanolamine. In grey all “O” = ether, “P” = plasmalogen species, nd = not detected. Values are the mean ± SD. In bold, p value < 0.05 after FDR calculation

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