Table 1 Baseline characteristics and hormone levels by sex
Characteristics | Women | Men |
|---|---|---|
N = 479,797 | 264,282 | 215,515 |
Oestradiol | ||
 Detectable [n (%)] | 57,904 (21.9) | 17,669 (8.2) |
 Undetectable [n (%)] | 177,202 (67.1) | 174,347 (80.9) |
 Missing [n (%)] | 29,176 (11.0) | 23,499 (10.9) |
 Oestradiol [pmol/L] | 396.7 (264.6, 634.4) | 204.1 (188.8, 230.8) |
Testosterone | ||
 Detectable [n (%)] | 210,584 (79.7) | 203,986 (94.7) |
 Undetectable [n (%)] | 39,692 (15.0) | 218 (0.1) |
 Missing [n (%)] | 14,006 (5.3) | 11,311 (5.2) |
 Testosterone [nmol/L] | 1.015 (0.723, 1.373) | 11.648 (9.457, 14.164) |
Oestradiol/testosterone (O/T ratio) | ||
 Oestradiol and testosterone detectable [n (%)] | 52,529 (19.9) | 17,580 (8.2) |
 O/T ratio (nmol/L) | 0.379 (0.237, 0.631) | 0.016 (0.013, 0.021) |
Sex hormone–binding globulin (SHBG) |  |  |
 SHBG detectable [n (%)] | 226,690 (85.8) | 188,864 (87.6) |
 SHBG [nmol/L] | 56.48 (40.05, 77.36) | 36.93 (27.90, 48.18) |
Free androgen index (FAI) | ||
 FAI detectable [n (%)] | 190,490 (72.1) | 187,797 (87.1) |
 FAI nmol/L | 1.80 (1.14, 2.85) | 31.32 (25.21, 39.28) |
Baseline characteristics and physical measures | ||
 Age (years) | 57.0 (50.0, 63.0) | 58.0 (50.0, 63.0) |
 Systolic blood pressure (mmHg) | 133.0 (121.0, 147.0) | 139.5 (129.0, 151.5) |
 Current smoking [n (%)] | 23,314 (8.8%) | 26,578 (12.3%) |
 BMI kg/m2 | 26.09 (23.43, 29.68) | 27.25 (24.94, 29.97) |
 Waist circumference (cm) | 83.0 (75.0, 92.0) | 96.0 (89.0, 103.0) |
 Waist to hip ratio % | 81.25 (76.74, 86.32) | 93.27 (89.22, 97.35) |
 Waist to height ratio % | 51.10 (46.30, 56.89) | 54.49 (50.76, 58.82) |
 Body fat % | 36.7 (32.0, 41.3) | 25.3 (21.5, 29.0) |
 Total cholesterol [mmol/L] | 5.8 (5.1, 6.6) | 5.5 (4.8, 6.2) |
 LDL cholesterol [mmol/L] | 3.8 (3.0, 4.2) | 3.5 (2.9, 4.1) |
 HDL cholesterol [mmol/L] | 1.55 (1.32, 1.82) | 1.24 (1.07, 1.46) |
 Diabetes, [n (%)] | 9649 (3.7) | 13,763 (6.4) |
 Townsend deprivation Index | − 2.16 (−3.65, 0.44) | −2.16 (−3.67, 0.57) |