Fig. 4
Aβ1–42 administration also alters spatial and non-associative memory retrieval in both female and male mice. A An OLM test was performed, changing the location of one object between the training and each memory test (OLM1 and OLM2). Treatment was administered icv. between OLM1 and OLM2 to evaluate memory retrieval. B Discrimination index during the training, OLM1, and OLM2 sessions. Data is expressed as the mean ± SEM. C An OF habituation test was carried out by submitting the animals to the same OF arena twice, administering the icv. injection between the training and the retrieval sessions. D Total distance traveled during the two OF sessions (training -OF1- and retrieval -OF2- sessions). Data is expressed as the percentage (%) of the distance traveled in the training session (OF1). E Examples of mice movement tracked during OF1 and OF2 for the different treatment groups. N vehicles: males = 8–9 and females = 7; N Aβ1–42: males = 9–10 and females = 7–8; N reverse Aβ42–1: males = 8–9 and females = 6. Aβ, Amyloid-β; icv., intracerebroventricular; OF, open field; OLM, object location memory. *p < 0.05, **p < 0.01, ***p < 0.001 vs. vehicle of the corresponding sex; #p < 0.05, ##p < 0.01 vs. reverse Aβ42–1 of the corresponding sex; ‡‡p < 0.01, ‡‡‡p < 0.001 vs. OF1