Fig. 3
Aβ1–42 administration similarly alters non-associative exploratory habituation memory encoding in both female and male mice. A An OF habituation test was carried out by submitting the animals to the same OF arena twice, on consecutive days 15 and 16 post-icv. injection. B Total distance traveled during the two OF sessions (training -OF1- and retrieval -OF2- sessions). Data is expressed as the percentage (%) of the distance traveled in the training session (OF1). C Examples of mice movement tracked during OF1 and OF2 for the different treatment groups. N vehicles: males = 7 and females = 12; N Aβ1–42: males = 9 and females = 10; N reverse Aβ42–1: males = 7 and females = 6. Aβ, Amyloid-β; icv., intracerebroventricular; OF, open field. * p < 0.05, ** p < 0.01 vs. vehicle of the corresponding sex; # p < 0.05, ## p < 0.01 vs. Aβ42–1 of the corresponding sex; ‡ p < 0.05, ‡‡ p < 0.01, ‡‡‡ p < 0.001 vs. OF1