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Fig. 5 | Biology of Sex Differences

Fig. 5

From: Sex differences in renal cell carcinoma: a single-cell analysis reveals exhausted CD8+ T-cells highly infiltrated in males

Fig. 5

Androgen contributes to the dysfunction and exhaustion of CD8+ T-cells. A Correlation analysis between T-cells status score and androgen response score. B The FCM of human CD8+ T-cells in androgen culture. C CD8+ T-cells toxicity of OT-I mice in androgen culture. D IHC and ELISA analysis of 44 RCC patients receiving immunotherapy in SYSUCC (males: 32; females: 12). E Prognostic analysis of male RCC patients in different serum androgen after immunotherapy in SYSUCC. ELISA: enzyme-linked immunosorbent assay; FCM: flow cytometry; IHC: immunohistochemistry; HR: hazard ratio. RCC: renal cell carcinoma; SYSUCC: Sun Yat-sen University Cancer Center

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Biology of Sex Differences

ISSN: 2042-6410

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