Fig. 3
From: Sex differences in muscle protein expression and DNA methylation in response to exercise training
The effect of sex on the proteome and DNA methylome associations with cardiorespiratory fitness. A Volcano plot showing the effect of sex on cardiorespiratory fitness (CRF; baseline VO2max) on the 2317 tested proteins. X-axis is the log2 of fold change in males compared to females; y-axis is the –log10 of unadjusted p-value. No significant proteins were identified (π-value < 0.005; computed according to [35]). B Volcano plot showing the effect of sex on CRF on the 641,715 tested CpGs. The six differentially methylated positions (DMPs) at a false discovery rate (FDR) < 0.005 are displayed in colours, with red dots denoting DMPs with a larger coefficient in males, and blue dots denoting DMPs with a lower coefficient in males. Dotplot to the right displays DNAm beta-values of the denoted DMP in Gene SMART cohort individuals corresponding to CRF, coloured by sex. Plotted beta values, residuals from batch produced similar results. C Histogram of raw p-values for the sex-specific effect on the proteome. D Histogram of raw p-values for the sex-specific effect on the methylome