Fig. 3

Overview of differentially expressed genes and pathways in vastus lateralis muscle RNA-seq data. A Volcano plots and Venn diagrams displaying the amount of differentially expressed genes in the weakest vs. fittest older adults (females in brown, left, and males in blue, right). B The top 15 differentially expressed pathways in the weakest vs. fittest female older adults. C A protein–protein interaction map of all female DEGs. Lines connecting DEGs indicate an interaction between those DEGs on protein level. D The top 15 differentially expressed pathways in the weakest vs. fittest male older adults. E A protein–protein interaction map of all male DEGs. Lines connecting DEGs indicate an interaction between those DEGs on protein level