Table 3 Gamma regression models showing significant associations of aortic valve calcification (AVC) score with age and inflammation in male patients with kidney failure (KF)
AVC score | Males (n = 209) | |||||
|---|---|---|---|---|---|---|
Univariate | Multivariate†| |||||
Estimate | 95% CI | p-value | Estimate | 95% CI | p-value | |
Age | 1.14 | 1.11–1.17 |  < 0.001 | 1.29 | 1.07–1.14 |  < 0.001 |
Body mass index, kg/m2 | 0.89 | 0.84–0.94 |  < 0.001 | – | – | – |
SBP, mmHg | 0.96 | 0.95–0.97 |  < 0.001 | – | – | – |
DBP, mmHg | 0.93 | 0.90–0.97 |  < 0.001 | – | – | – |
DM, yes | 0.11 | 0.07–0.16 |  < 0.001 | – | – | – |
Renal replacement therapy | 10.42 | 6.80–16.00 |  < 0.001 | – | – | – |
Malnutrition, SGA > 1 | 0.10 | 0.06–0.17 |  < 0.001 | – | – | – |
ACE-inhibitors/ARBs | 17.63 | 9.96–31.20 |  < 0.001 | – | – | – |
Beta-blockers | 22.65 | 12.52–40.97 |  < 0.001 | – | – | – |
Ca2+ channel blockers | 2.80 | 0.93–8.48 | 0.070 | – | – | – |
Statins | 0.47 | 0.20–1.11 | 0.085 | – | – | – |
Cholesterol, mmol/L | 5.04 | 3.64–6.98 |  < 0.001 | – | – | – |
HDL, mmol/L | 0.18 | 0.12–0.29 |  < 0.001 | – | – | – |
Triglycerides, mmol/L | 0.41 | 0.31–0.53 |  < 0.001 | – | – | – |
Lipoprotein(a), mmol/L | 0.99 | 0.997 -0.998 |  < 0.001 | – | – | – |
Apolipoprotein-A1, g/L | 0.06 | 0.03–0.12 |  < 0.001 | – | – | – |
Creatinine, µmol/L | 1.01 | 1.005 -1.008 |  < 0.001 | – | – | – |
Haemoglobin, g/L | 0.86 | 0.85–0.88 |  < 0.001 | – | – | – |
TNF, pg/mL | 0.90 | 0.80–1.02 | 0.109 | – | – | – |
IL-6, pg/mL | 2.61 | 2.29–2.98 |  < 0.001 | 1.16 | 1.04–1.29 | 0.010 |
AGE, skin AF | 2.56 | 0.86–7.62 | 0.093 | – | – | – |
GDF-15, ng/mL | 4.47 | 3.62–5.52 |  < 0.001 | – | – | – |
YKL-40, ng/mL | 1.02 | 1.02–1.03 |  < 0.001 | – | – | – |