Skip to main content

Table 4 Association of plaque skewing with secondary cardiovascular endpoints during 3-years follow-up

From: X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events

XCI skewing

Crude analysis

Adjusted for BMI and Smoking

Hazard ratio [95% CI]

P value

Hazard ratio [95% CI]

P value

Composite event

 Dichotomous (Non-skewed)

(1.0) ref.

–

(1.0) ref.

–

 Dichotomous (Skewed)

1.70 [0.91 to 3.19]

0.1

1.82 [0.96 to 3.45]

0.07

 Continuously*

1.24 [0.96 to 1.62]

0.1

1.21 [0.93 to 1.57]

0.15

Major cardiovascular event (MACE)

 Dichotomous (Non-skewed)

(1.0) ref.

–

(1.0) ref.

–

 Dichotomous (Skewed)

0.89 [0.30 to 2.65]

0.84

0.80 [0.25 to 2.53]

0.7

 Continuously*

0.98 [0.59 to 1.62]

0.94

0.81 [0.47 to 1.41]

0.46

Peripheral artery event

 Dichotomous (Non-skewed)

(1.0) ref.

–

(1.0) ref.

–

 Dichotomous (Skewed)

2.85 [1.25 to 6.47]

0.012

3.14 [1.38 to 7.18]

0.007

 Continuously*

1.45 [1.07 to 1.97]

0.018

1.46 [1.09 to 1.97]

0.011

  1. *Calculated for 10 points percentage of XCI skewing