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Table 3 Effect of classical cardiovascular risk factors on the association between plaque skewing and plaque hemorrhage

From: X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events

XCI skewing

Plaque hemorrhage (major)

Odds ratio [95% CI]

P value

Dichotomous (Non-skewed)

(1.0) ref.

–

Dichotomous (Skewed)

1.50 [0.79 to 2.87]

0.22

Continuously*

1.44 [1.06 to 1.98]

0.02

Adjusted for: Age

 Dichotomous (Non-skewed)

(1.0) ref.

–

 Dichotomous (Skewed)

1.49 [0.78 to 2.86]

0.22

 Continuously*

1.43 [1.06 to 1.98]

0.02

Adjusted for: BMI

 Dichotomous (Non-skewed)

(1.0) ref.

–

 Dichotomous (Skewed)

1.49 [0.76 to 2.97]

0.25

 Continuously*

1.37 [0.99 to 1.94]

0.07

Adjusted for: Smoking

 Dichotomous (Non-skewed)

(1.0) ref.

–

 Dichotomous (Skewed)

1.62 [0.84 to 3.14]

0.15

 Continuously*

1.50 [1.10 to 2.09]

0.01

Adjusted for: Diabetes Mellitus

 Dichotomous (Non-skewed)

(1.0) ref.

–

 Dichotomous (Skewed)

1.50 [0.79 to 2.87]

0.22

 Continuously*

1.44 [1.06 to 1.98]

0.02

Adjusted for: GFR (MDRD)

 Dichotomous (Non-skewed)

(1.0) ref.

–

 Dichotomous (Skewed)

1.46 [0.77 to 2.80]

0.25

 Continuously*

1.44 [1.06 to 1.99]

0.02

Adjusted for: BMI + Smoking

 Dichotomous (Non-skewed)

(1.0) ref.

–

 Dichotomous (Skewed)

1.53 [0.77 to 3.05]

0.23

 Continuously*

1.38 [0.99 to 1.96]

0.06

  1. *Calculated for 10 points percentage of XCI skewing