Locus (SNP) | ULR* | |||||||
---|---|---|---|---|---|---|---|---|
T2D diagnosis ≤ 45 years | T2D diagnosis ≥ 46 years | |||||||
Females (n = 1662) | Males (n = 1404) | Females (n = 1596) | Males (n = 1384) | |||||
OR (95% CI) | p-Wald | OR (95% CI) | p-Wald | OR (95% CI) | p-Wald | OR (95% CI) | p-Wald | |
Group 1 | ||||||||
INS-IGF2 (rs149483638) | 1.06 (0.8–1.3) | 0.61 | 1.38 (1.1–1.8)a | 0.014 | 1.1 (0.9–1.4) | 0.44 | 1.56 (1.2–2)a | 0.0010 |
INS (rs689) | 1.09 (0.8–1.4) | 0.52 | 1.63 (1.2–2.1)a | 0.0003 | 1.23 (1–1.6)a | 0.11 | 1.43 (1.1–1.9)a | 0.012 |
KCNQ1 (rs2237897) | 1.31 (1.1–1.6) | 0.016 | 1.97 (1.5–2.5)a | < 0.0001 | 1.09 (0.9–1.4) | 0.46 | 1.56 (1.2–2)a | 0.0002 |
CDKN1C (rs163168) | 1.36 (1.1–1.7)a | 0.0043 | 1.82 (1.4–2.3)a | < 0.0001 | 1.05 (0.8–1.3) | 0.64 | 1.45 (1.2–1.8)a | 0.0015 |
SLC22A18 (rs450208) | 1.46 (1.2–1.9)a | 0.0014 | 1.27 (1–1.6) | 0.053 | 1.38 (1.1–1.8)a | 0.0092 | 1.36 (1.1–1.8) | 0.015 |
Group 2 | ||||||||
IGF2BP2 (rs4402960) | 1.16 (0.9–1.5) | 0.26 | 1.65 (1.2–2.2)a | 0.0007 | 1.09 (0.8–1.4) | 0.54 | 1.37 (1–1.9) | 0.042 |
TCF7L2 (rs7903146) | 1.22 (0.9–1.6)a | 0.15 | 2.21 (1.6–3)a | < 0.0001 | 1.15 (0.9–1.5) | 0.34 | 1.83 (1.3–2.5)a | 0.0003 |
CDKN2A (rs10811661) | 1.47 (1–2.2)a | 0.049 | 0.92 (0.6–1.3) | 0.65 | 1.07 (0.7–1.5) | 0.73 | 1.08 (0.7–1.6) | 0.72 |
SLC30A8 (rs3802177) | 1.31 (1–1.6)a | 0.018 | 1.43 (1.1–1.8)a | 0.0034 | 0.95 (0.7–1.2)a | 0.65 | 0.96 (0.7–1.2) | 0.77 |
HNF1A (rs483353044) | 1.92 (0.4–9.5) | 0.43 | 1.97 (0.5–7.9) | 0.34 | 2.85 (0.6–12.8)a | 0.17 | 1.53 (0.3–6.9) | 0.58 |
WFS1 (rs4458523) | 1.08 (0.8–1.4) | 0.52 | 1.3 (1–1.7)a | 0.065 | 0.99 (0.8–1.3) | 0.95 | 0.99 (0.8–1.3) | 0.94 |
HMG20A (rs1005752) | 0.97 (0.8–1.2) | 0.81 | 1.04 (0.8–1.3) | 0.73 | 0.87 (0.7–1.1)a | 0.19 | 0.88 (0.7–1.1)a | 0.27 |
Group 3 | ||||||||
SLC16A11 (rs75493593) | 1.51 (1.2–1.9)a | < 0.0001 | 1.34 (1.1–1.7)a | 0.011 | 1.24 (1–1.5)a | 0.048 | 1.14 (0.9–1.4)a | 0.27 |
IRS1 (rs1801278) | 0.58 (0.3–1.2) | 0.14 | 0.94 (0.5–1.9) | 0.87 | 1.21 (0.7–2.2)a | 0.53 | 1.35 (0.7–2.6) | 0.38 |
FABP2 (rs1799883) | 0.89 (0.7–1.1) | 0.34 | 1.23 (1–1.6)a | 0.11 | 0.93 (0.7–1.2) | 0.57 | 0.93 (0.7–1.2) | 0.60 |
CAPN10 (rs7607759) | 0.76 (0.5–1.2)a | 0.23 | 1.06 (0.6–1.8) | 0.83 | 1.17 (0.8–1.8) | 0.46 | 1.26 (0.8–2.1) | 0.37 |
PPP1R3A (rs1799999) | 1.36 (1.1–1.7)a | 0.0061 | 0.83 (0.6–1.1) | 0.14 | 1.25 (1–1.6)a | 0.060 | 0.94 (0.7–1.2) | 0.64 |
PTPRD (rs10511567) | 1.28 (1–1.6)a | 0.029 | 0.76 (0.6–1)a | 0.036 | 1.16 (0.9–1.5)a | 0.22 | 0.9 (0.7–1.1) | 0.39 |
Group 4 | ||||||||
IL6 (rs1800795) | 0.8 (0.5–1.2) | 0.25 | 1.02 (0.7–1.6) | 0.94 | 0.82 (0.6–1.2) | 0.32 | 1.67 (1.1–2.5)a | 0.0093 |
NOS3 (rs2070744) | 0.71 (0.5–1)a | 0.028 | 0.86 (0.6–1.2)a | 0.38 | 0.85 (0.6–1.1) | 0.28 | 0.99 (0.7–1.4) | 0.96 |
CPED1 (rs10261386) | 0.95 (0.8–1.2) | 0.62 | 1.1 (0.9–1.4) | 0.42 | 0.94 (0.8–1.2) | 0.61 | 1.23 (1–1.5) | 0.088 |
KHDRBS3 (rs6577691) | 0.9 (0.7–1.2) | 0.52 | 0.73 (0.5–1)a | 0.083 | 1.02 (0.7–1.4) | 0.91 | 0.68 (0.5–1)a | 0.046 |
CACNA1H (rs4984636) | 0.89 (0.6–1.2) | 0.49 | 0.97 (0.7–1.4) | 0.86 | 0.54 (0.4–0.8)a | 0.0022 | 0.97 (0.7–1.4) | 0.87 |
No. of SNPs | 9 | 12 | 4 | 10 | ||||
Sum of univariate R2 | 0.056 | 0.14 | 0.02 | 0.079 |