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Table 2 Association of 23 SNPs with type 2 diabetes in the total population. (N = 4040 chromosomes)

From: Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study

Locus (SNP)

Chr

Position

RA

AA

MAF

ULR*

      

OR (95% CI)

p-Wald

R2

SI (p-Wald)

Group 1

         

 INS-IGF2 (rs149483638)

11

2,140,300

C

Ta

0.281

1.25 (1.1–1.4)

0.0022

0.003

0.035

 INS (rs689)

11

2,160,994

Aa

T

0.188

1.32 (1.1–1.5)

0.0005

0.004

0.062

 KCNQ1 (rs2237897)

11

2,837,316

C

Ta

0.392

1.44 (1.3–1.6)

 < 0.0001

0.010

0.004

 KCNQ1 (rs163168)

11

2,803,115

C

Ta

0.436

1.39 (1.2–1.6)

 < 0.0001

0.008

0.019

SLC22A18 (rs450208)

11

2,910,751

T

Ga

0.311

1.38 (1.2–1.6)

 < 0.0001

0.007

 > 0.1

Group 2

         

 IGF2BP2 (rs4402960)

3

185,793,899

Ta

G

0.163

1.28 (1.1–1.5)

0.0031

0.003

0.073

 TCF7L2 (rs7903146)

10

112,998,590

Ta

C

0.121

1.5 (1.3–1.8)

 < 0.0001

0.007

0.004

 CDKN2A (rs10811661)

9

22,134,095

T

Ca

0.096

1.12 (0.9–1.4)

0.29

0

 > 0.1

 SLC30A8 (rs3802177)

8

117,172,786

Aa

G

0.272

1.15 (1–1.3)

0.044

0.001

 > 0.1

 HNF1A (rs483353044)

12

120,999,288

Aa

G

0.003

2 (0.8–5)

0.13

0.001

 > 0.1

 WFS1 (rs4458523)

4

6,288,259

G

Ta

0.233

1.07 (0.9–1.2)

0.35

0

 > 0.1

 HMG20A (rs1005752)

15

77,525,786

Ca

A

0.419

0.94 (0.8–1.1)

0.34

0

 > 0.1

Group 3

         

 SLC16A11 (rs75493593)

17

7,041,768

Ta

G

0.374

1.31 (1.2–1.5)

 < 0.0001

0.006

 > 0.1

 IRS1 (rs1801278)

2

226,795,828

Ta

C

0.027

0.98 (0.7–1.4)

0.91

0

 > 0.1

 FABP2 (rs1799883)

4

119,320,747

Ta

C

0.241

0.99 (0.9–1.1)

0.89

0

 > 0.1

 CAPN10 (rs7607759)

2

240,596,709

Ga

A

0.053

1.04 (0.8–1.4)

0.76

0

 > 0.1

 PPP1R3A (rs1799999)

7

113,878,379

Aa

C

0.291

1.09 (0.9–1.2)

0.23

0

0.006

PTPRD (rs10511567)

9

11,606,348

Ca

T

0.278

1.02 (0.9–1.2)

0.76

0

0.005

Group 4

         

 IL6 (rs1800795)

7

22,727,026

Ca

G

0.079

1.01 (0.8–1.3)

0.93

0

0.033

NOS3 (rs2070744)

7

150,992,991

Ca

T

0.145

0.84 (0.7–1)

0.054

0.001

 > 0.1

 CPED1 (rs10261386)

7

120,711,855

Ca

T

0.347

1.04 (0.9–1.2)

0.55

0

 > 0.1

 KHDRBS3 (rs6577691)

8

135,961,229

Ga

T

0.123

0.84 (0.7–1)

0.076

0.001

 > 0.1

 CACNA1H (rs4984636)

16

1,202,441

Ca

T

0.113

0.83 (0.7–1)

0.073

0.001

 > 0.1

No. genes

     

12

Sum of univariate R2

     

0.053

  1. AA alternative allele, RA risk allele, Chr chromosome, CI confidence interval, MAF major allele frequency, OR odds ratio, R2 variability of T2D explained by the SNP, SI sex interaction, SNP single nucleotide polymorphism, ULR univariate logistic regression
  2. aMinor allele. Group 1, genes associated with insulin production located in the chromosome region 11p15.5; Group 2, genes associated with insulin production located in other chromosomes; Group 3, genes associated with peripheral insulin resistance; Group 4, genes associated with inflammation, and other functions
  3. *The power (1 − β error probability) > 0.99 for all SNPs with P < 0.1
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Biology of Sex Differences

ISSN: 2042-6410

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