Sex-associated differences in mitochondrial function in human peripheral blood mononuclear cells (PBMCs) and brain

Table 2 Measures of peripheral mitochondrial function and cerebral metabolism

	Women n = 15	Men n = 9	p value	η ²
O2k-Oxygraph [pmol/(s*IU CS)]
Endogenous	205.8 ± 12.4	145 ± 14.8	0.007**	0.40
CI	453.6 ± 36.0	313 ± 39.6	0.02*	0.30
CI+II	1096.0 ± 86.4	814.5 ± 76.1	0.03*	0.27
ETS	1028 ± 94.8	772.2 ± 69.1	0.04*	0.22
CII_ETS	612.8 ± 42.3	448.5 ± 34.5	0.008**	0.36
CIV	1495 ± 104.6	1045 ± 85.12	0.004**	0.40
CS activity [IU/10⁶ cells]	0.2914 ± 0.019	0.2211 ± 0.025	0.04*	0.29
ATP levels [μM/10⁵ cells]	2.50 ± 0.2	2.20 ± 0.3	0.45	0.04
NAA in GM [mmol/l]	12.27 ± 0.19	11.35 ± 0.25	0.009**	0.35
NAA in WM [mmol/l]	14.79 ± 0.38	13.32 ± 0.40	0.01*	0.25

Mean ± SEM, unpaired t test with Welch’s correction, significant differences are marked by asterisk, (*p<0.05; **p<0.01)
ATP adenosine triphosphate, CS citrate synthase, C complex, ETS electron transport system, GM gray matter, NAA N-acetylaspartate, WM white matter

ISSN: 2042-6410