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Table 3 Relative mRNA levels of cytokines in inguinal and perigonadal adipose tissue at postnatal days (PND) 10, 21, 30, 50, 85, and 150 in male (M) and female (F) rats raised in litters (L) 4 or 12 pups

From: Age and sex dependent effects of early overnutrition on metabolic parameters and the role of neonatal androgens

 

Il1β mRNA inguinal

IL6 mRNA inguinal

TNFα mRNA inguinal

Il1β mRNA perigonadal

IL6 mRNA perigonadal

TNFα mRNA perigonadal

ML12PND10d

100.0 ± 21.3

100.0 ± 10.5

100.0 ± 10.5

TNA

TNA

TNA

ML4PND10d

100.5 ± 29.6

99.6 ± 56.6

88.9 ± 13.2

TNA

TNA

TNA

FL12PND10d

156.4 ± 44.6

94.9 ± 22.4

89.8 ± 12.3

TNA

TNA

TNA

FL4PND10d

32.4 ± 13.3a

38.7 ± 12.1

54.3 ± 11.1

TNA

TNA

TNA

ML12PND21d

100.0 ± 55.4

100.0 ± 38.7

100.0 ± 28.9

100.0 ± 23.7

100.0 ± 18.5

100.0 ± 21.5

ML4PND21d

42.5 ± 9.3

19.3 ± 1.7a

95.0 ± 25.7

70.3 ± 21.5

339.8 ± 73.8a

161.4 ± 53.6

FL12PND21d

97.8 ± 42.5

112.3 ± 46.6

142.1 ± 32.9

18.4 ± 4.7b

72.8 ± 20.1

50.2 ± 13.8

FL4PND21d

51.3 ± 23.6

20.7 ± 8.2a

41.7 ± 6.3

36.2 ± 8.1

331.0 ± 79.9a

75.4 ± 13.2

ML12PND85

BLD

BLD

BLD

100.0 ± 42.1

100.0 ± 28.9

100.0 ± 28.8

ML4PND85

BLD

BLD

BLD

70.0 ± 19.3

124.3 ± 30.3

124.3 ± 30.3

FL12PND85

BLD

BLD

BLD

47.7 ± 29.1

25.5 ± 20.1b

31.8 ± 24.7b

FL4PND85

BLD

BLD

BLD

51.0 ± 23.5

22.9 ± 12.4b

15.8 ± 9.1 b

ML12PND150

BLD

BLD

BLD

100.0 ± 29.5

BLD

100.0 ± 39.5

ML4PND150

BLD

BLD

BLD

80.5 ± 37.0

BLD

450.5 ± 186.6 a

FL12PND150

BLD

BLD

BLD

703.9 ± 142.6b

BLD

211.0 ± 49.4

FL4PND150

BLD

BLD

BLD

617.3 ± 145.8b

BLD

256.4 ± 65.2

  1. N = 5–6 in each experimental group at each age
  2. TNA tissue not available, BLD below limit of detection
  3. aDifferent from rats of same age and sex (litter effect)
  4. bDifferent from males of same age and litter size
  5. cDifferent from preceding age (same sex and litter size)
  6. dNon-fasting samples