Fig. 6

High-throughput phenotyping of two consomic panels in the rat. a The percent of significantly altered phenotypes due to crossing each chromosome in two separate consomic panels (BN to FHH in black and BN to SS in red) shown per megabase (Mb) or per ten genes of the chromosome. b Phenotypes identified in a to be significantly altered by the two MSY consomic rats (FHH-YBN/Mcwi in black and SS-YBN/Mcwi in red) were then separated based on if a significant difference between males and females was also seen for one or both strains used to produce the consomic rat. Phenotypes that had a sex difference in one specific strain are listed in each category. Two phenotypes were identified to overlap in the two consomic rats with a BN-specific sex difference, dilator response to acetylcholine EC50 and dilator response to acetylcholine Log EC50. c, d The dilator response to acetylcholine EC50 for male (black) and female (gray) BN and FHH (c) or SS (d) rats showing BN to have the largest sex difference. MSY consomic significantly decreased the response in both FHH (c) and SS (d) consomic rats (red). The chromosome 15 consomic rats (FHH-15BN/Mcwi and SS-15BN/Mcwi) resulted in a greater sex difference for both strains. Error bars represent the SEM of independently tested rats and asterisk represents an adjusted P value <0.05 calculated with Mann-Whitney test followed by a Bonferroni adjustment