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Table 1 BDNF, general characteristics, thrombocyte measures

From: Serum brain-derived neurotrophic factor (BDNF) is not regulated by testosterone in transmen

 

Baseline

After 12 months

 

Mean

S.E.M.

Mean

S.E.M.

p

ENIGI transmen

 General characteristics

  Age (years)

29.1

1.8

   

  BMI (kg/m2)

24.2

1.0

25.2

0.9

0.016

  Weight (kg)

66.5

3.1

69.8

3.0

0.007

  Waist (cm)

77.4

2.6

79.8

2.5

n.s.

 Laboratory measures

  BDNF (pg/ml)

5635.1

291.0

5573.4

302.2

n.s.

  FSH (U/L)

6.2

1.5

4.5

2.1

n.s.

  LH (U/L)

8.3

1.6

10.4

4.8

n.s.

  Estradiol (pg/mL)

116.5

14.5

51.6

8.7

0.002

  Testosterone total (ng/dL)

42.1

8.4

653.3

44.2

<0.001

  Testosterone free (nmol/L)

0.4

0.1

13.6

1.2

<0.001

  SHBG (nmol/L)

78.0

8.9

36.2

2.7

<0.001

 Lifestyle

  Sports index

2.9

0.9

2.8

0.9

n.s.

  Work index

2.8

0.9

3.0

0.9

n.s.

  Freetime index

2.8

0.9

3.0

0.9

n.s.

 

N

%

N

%

 

  Current smoking

7

24.1

3

10.2

n.s.

 

Baseline

3–7 months

8–18 months

 
 

Mean

S.E.M.

Mean

S.E.M.

Mean

S.E.M.

 

MPIP transmen

 General characteristics

       

  Age (years)

27.2

0.6

     

  BMI (kg/m2)

23.6

0.8

24.8

0.8

24.9

0.8

<0.001

 Laboratory measures

  FSH (U/L)

6.3

0.6

5.8

0.9

12.8

5.3

n.s.

  LH (U/L)

12.2

2.2

5.9

1.5

9.8

3.3

0.01

  Estradiol (pg/mL)

113.2

17.5

129.3

42.8

66.0

11.2

0.022

  Testosterone total (nmol/L)

3.0

0.8

24.3

12.8

2.5

3.2

<0.001

 Lifestyle

  Current smoking

N

%

N

%

N

%

 

   Yes

6

15.8

5

13.2

4

10.5

n.s

   No

32

84.2

28

73.7

28

73.7

n.s.

   Not documented

  

5

13.2

6

15.8

n.s

 Thrombocyte measures

Mean

S.E.M.

Mean

S.E.M.

Mean

S.E.M.

 

  Thrombocyte count (10^9/l)

270.3

11.4

270.1

11.5

277.6

26.3

n.s.

  Mean thrombocyte volume (fl)

10.3

0.2

10.4

0. 2

10.4

0.2

n.s.

  1. ENIGI European Network for the Investigation of Gender Incongruence, BDNF brain-derived neurotrophic factor, MPIP Max Planck Institute of Psychiatry
  2. Twelve months of CSH resulted in significant changes in sex hormones in both cohorts. In contrast to our initial hypothesis, we did however not observe any statistically significant effect of the treatment on BDNF levels in transmen
  3. P-values in italic indicate a significant difference
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Biology of Sex Differences

ISSN: 2042-6410

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