Fig. 2

Sex and genotype differences in levels of selected Hsa21-encoded proteins. Bar graphs indicate the percent (%) increase or decrease in each comparison. HP hippocampus, CB cerebellum, CR cortex, C controls, females vs. males; T trisomic (Dp10) females vs. Dp10 males; M male Dp10 vs. male controls; F female Dp10 vs. female controls. Asterisk significant difference by three-level mixed effects model after Benjamini-Hochberg correction, with 5 % false discovery rate. n, not measured. Error bars indicate the SEM. a–c Proteins are encoded by genes trisomic in the Dp10 mice. d, e Genes encoding APP and ITSN1 map to Mmu16 and PKNOX1 maps to Mmu17 and are not trisomic in the Dp10