Measure | Two-way RM ANOVA (treatment × time) | Three-way RM ANOVA (treatment × sex × time) | |||
---|---|---|---|---|---|
Females | Males | ||||
Figure | Â | Figure | Â | ||
Clinical scores | Figure 1A | Day: F23,506 = 25.1, P < 0.001 | Figure 1B | Day: F23,437 = 14.3, P < 0.001 | Day: F23,943 = 37.1, P < 0.001 |
Treatment: F1,22 = 9.0, P < 0.01 | Treatment: F1,19 = 8.6, P < 0.01 | Treatment: F1,41 = 16.9, P < 0.001 | |||
Day × treatment: F23,506 = 3.2, P < 0.05 | Day × treatment: F23,437 = 2.2, P < 0.01 | Sex: F1,41 = 0.5, P = 0.4 | |||
 |  | Treatment × sex: F1,41 = 0.2, P = 0.6 | |||
Day × treatment: F23,943 = 2.8, P < 0.01 | |||||
Day × sex: F23,943 = 1.3, P = 0.2 | |||||
Day × sex × treatment: F23,943 = 0.4, P = 0.8 | |||||
Grip strength | Figure 1C | Day: F9,198 = 3.3, P < 0.001 | Figure 1D | Day: F9,171 = 3.7, P < 0.001 | Day: F9,369 = 5.8, P < 0.001 |
Treatment: F1,22 = 2.0, P = 0.17 | Treatment: F1,19 = 7.3, P < 0.05 | Treatment: F1,41 = 8.2, P < 0.01 | |||
Day × treatment: F9,198 = 1.2, P = 0.3 | Day × treatment: F9,171 = 1.3, P = 0.2 | Sex: F1,41 = 32.7, P < 0.001 | |||
 |  | Treatment × sex: F1,41 = 0.7, P = 0.4 | |||
Day × treatment: F9,369 = 1.9, P < 0.05 | |||||
Day × sex: F9,369 = 1.2, P = 0.2 | |||||
Day × sex × treatment: F9,369 = 0.6, P = 0.7 | |||||
Weight | Figure 1E | Day: F22,484 = 16.0, P < 0.001 | Figure 1 F | Day: F22,418 = 49.7, P < 0.001 | Day: F22,902 = 54.4, P < 0.001 |
Treatment: F1,22 = 0.2, P = 0.6 | Treatment: F1,19 = 0.06, P = 0.8 | Treatment: F1,41 = 0.2, P = 0.6 | |||
Day × treatment: F22,484 = 0.8, P = 0.5 | Day × treatment: F22,418 = 0.6, P = 0.9 | Sex: F1,41 = 1.4, P = 0.2 | |||
 |  | Treatment × sex: F1,41 = 0.005, P = 0.9 | |||
Day × treatment: F22,902 = 0.6, P = 0.7 | |||||
Day × sex: F22,902 = 3.2, P < 0.01 | |||||
Day × sex × treatment: F22,902 = 0.7, P = 0.6 | |||||
Mechanical thresholds | Figure 2A | Day: F9,198 = 4.2, P < 0.001 | Figure 2B | Day: F9,171 = 2.0, P < 0.05 | Day: F9,369 = 4.8, P < 0.001 |
Treatment: F1,22 = 13.8, P < 0.01 | Treatment: F1,19 = 1.3, P = 0.2 | Treatment: F1,41 = 10.2, P < 0.01 | |||
Day × treatment: F9,198 = 4.5, P < 0.001 | Day × treatment: F9,171 = 0.5, P = 0.8 | Sex: F1,41 = 7.3, P < 0.05 | |||
 |  | Treatment × sex: F1,41 = 1.6, P = 0.2 | |||
 |  |  |  |  | Day × treatment: F9,369 = 2.8, P < 0.01 |
 |  |  |  |  | Day × sex: F9,369 = 0.8, P = 0.5 |
 |  |  |  |  | Day × sex × treatment: F9,369 = 1.1, P = 0.3 |
Acetone withdrawal | Figure 2C | Day: F9,198 = 14.5, P < 0.001 | Figure 2D | Day: F9,171 = 7.0, P < 0.001 | Day: F9,369 = 20.2, P < 0.001 |
Treatment: F1,22 = 6.5, P < 0.05 | Treatment: F1,19 = 0.02, P = 0.8 | Treatment: F1,41 = 2.7, P = 0.16 | |||
Day × treatment: F9,198 = 8.2, P < 0.001 | Day × treatment: F9,171 = 0.6, P = 0.6 | Sex: F1,41 = 22.5, P < 0.001 | |||
 |  | Treatment × sex: F1,41 = 3.4, P = 0.07 | |||
Day × treatment: F9,369 = 4.3, P < 0.001 | |||||
Day × sex: F9,369 = 1.6, P = 0.13 | |||||
Day × sex × treatment: F9,369 = 5.2, P < 0.001 | |||||
Heat latency | Figure 2E | Day: F3,66 = 0.06, P = 0.9 | Figure 2F | Day: F3,57 = 1.8, P = 0.14 | Day: F3,123 = 1.052, P = 0.3 |
Treatment: F1,22 = 0.7, P = 0.3 | Treatment: F1,19 = 0.2, P = 0.5 | Treatment: F1,41 = 0.01, P = 0.8 | |||
Day × treatment: F3,66 = 1.8, P = 0.15 | Day × treatment: F3,57 = 0.2, P = 0.8 | Sex: F1,41 = 2.1, P = 0.14 | |||
 |  | Treatment × sex: F1,41 = 0.9, P = 0.3 | |||
Day × treatment: F3,123 = 1.5, P = 0.19 | |||||
Day × sex: F3,123 = 1.1, P = 0.3 | |||||
Day × sex × treatment: F3,123 = 0.3, P = 0.8 | |||||
AUC | Figure 2G | Mechanical thresholds: one-way ANOVA: F3,41 = 11.1, P < 0.001 | Figure 2H | Acetone withdrawal: one-way ANOVA: F3,41 = 13.2, P < 0.001 | Heat latency: one-way ANOVA: F3,41 = 0.8, P = 0.4 (Figure 2I) |