Table 3 Risk of death from colorectal cancer according to KRAS codons 12 and 13, and BRAF mutations
Entire cohort | Women | Men | ||||
|---|---|---|---|---|---|---|
HR (95% CI) | n(events) | HR (95% CI) | n(events) | HR (95% CI) | n(events) | |
KRAS status (unadjusted) | ||||||
Wild-type | 1.00 | 334 (113) | 1.00 | 177 (52) | 1.00 | 157 (61) |
Codon 12-mutated | 1.05 (0.76–1.45) | 156 (54) | 1.32 (0.85–2.05) | 83 (32) | 0.81 (0.50–1.32) | 73 (22) |
Codon 13-mutated | 1.94 (1.18–3.19) | 34 (18) | 2.58 (1.31–5.09) | 18 (10) | 1.42 (0.68–2.96) | 16 (8) |
KRAS status (adjusted) | ||||||
Wild-type | 1.00 | 273 (87) | 1.00 | 146 (39) | 1.00 | 127 (65) |
Codon 12-mutated | 1.02 (0.69–1.51) | 132 (44) | 1.29 (0.75–2.22) | 67 (24) | 0.74 (0.42–1.30) | 65 (20) |
Codon 13-mutated | 1.37 (0.74–2.54) | 28 (13) | 1.83 (0.79–4.23) | 15 (7) | 0.87 (0.34–2.72) | 13 (6) |
BRAF status (unadjusted) | ||||||
Wild-type | 1.00 | 446 (154) | 1.00 | 227 (75) | 1.00 | 219 (79) |
Mutated | 1.32 (0.90–1.94) | 78 (32) | 1.23 (0.74–2.04) | 50 (19) | 1.56 (0.87–2.81) | 28 (13) |
BRAF status (adjusted) | ||||||
Wild-type | 1.00 | 370 (122) | 1.00 | 184 (56) | 1.00 | 186 (66) |
Mutated | 1.56 (0.87–2.79) | 63 (22) | 1.47 ( 0.65–3.33) | 44 (14) | 3.50 (1.41–8.70) | 19 (8) |