Biology of Sex Differences

Table 1 In Vivo Hemodynamic Responses

From: Differential effects of androgens on coronary blood flow regulation and arteriolar diameter in intact and castrated swine

	Intacts			Castrates
Baseline CBF (mL/min)	33.46	±	5.10	35.63	±	4.94
% Δ Flow
T 1 nM	5.31	±	1.90 *	−0.84	±	2.43
T 10 nM	8.72	±	2.90 *†	2.57	±	1.62
T 100 nM	6.72	±	2.65 *	2.86	±	1.16 *
DHT 1 nM	12.17	±	5.62 *†	−1.64	±	3.29
DHT 10 nM	3.51	±	1.45 *	1.54	±	2.14
DHT 100 nM	6.94	±	2.44 *	2.08	±	1.20
EpiT 1 nM	7.85	±	4.07	4.38	±	2.63
EpiT 10 nM	8.09	±	3.71 *	4.80	±	2.44
EpiT 100 nM	3.59	±	1.78	2.60	±	3.56
Baseline MAP (mmHg)	64.93	±	8.99	76.33	±	8.85
% Δ Pressure
T 1 nM	−0.13	±	0.47	−0.23	±	0.38
T 10 nM	−0.51	±	0.38	−1.92	±	0.53 *
T 100 nM	−0.4	±	0.51	−1.64	±	0.49 *
DHT 1 nM	−0.78	±	0.52	−0.71	±	0.63
DHT 10 nM	−0.7	±	0.32	−1.12	±	0.74
DHT 100 nM	−0.33	±	0.26	−0.63	±	0.42
EpiT 1 nM	−0.37	±	0.53	−0.95	±	0.52
EpiT 10 nM	−0.38	±	0.33	−0.63	±	0.33
EpiT 100 nM	−0.64	±	0.40	−0.93	±	0.42 *

Coronary blood flow (CBF) and mean arterial pressure (MAP) responses to infusions of Testosterone (T), 5α-Dihydrotestosterone (DHT), and Epitestosterone (EpiT). *p < 0.05 vs. baseline, †p < 0.05 vs. castrates. n = 7-8 for intacts, n = 5-9 for castrates. Values are mean ± SEM.

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