Figure 3From: Sex differences in hypothalamic astrocyte response to estradiol stimulation Sex differences due to gonadal hormone effects in adult hypothalamic astrocytes. In four core genotype (FCG) mice, control astrocytes from XYM mice synthesized significantly less progesterone (P < 0.05) than control astrocytes from XXF, XYF and XXM mice. XXF and XYF astrocytes responded to estradiol (1 nmol/l) with increased progesterone synthesis (P < 0.05 versus their control), but XXM and XYM astrocytes did not (P > 0.05 versus their control). *Significantly different compared with all other controls (P < 0.05, ANOVA with Tukey-Fisher least significant difference post hoc test). †Significantly greater progesterone synthesis with 1 nmol/l estradiol compared with the control (P < 0.05, ANOVA with Tukey-Fisher least significant difference post hoc test).Back to article page