Skip to main content
Fig. 5 | Biology of Sex Differences

Fig. 5

From: Comparative developmental genomics of sex-biased gene expression in early embryogenesis across mammals

Fig. 5

Identifying conserved signals among orthologous genes across very early mouse and human embryonic stages. A An integrated UMAP analysis of human and mouse samples across embryonic stages separates mouse (two left clusters) and human (large right cluster). The two datasets were integrated using Seurat to identify common cell types. Four developmental stage-adjacent groups that include both mouse and human samples are denoted as S1, S2, S3, and S4. B–E The most conserved orthologs between mouse and human with respect to expression levels across each of the four developmental groups reveals similar positioning of ortholog expression between mouse (left) and human (right) clusters. Expression values were filtered to be within the 10th quantile of the integrated expression data. The top homologously expressed genes from the four developmental stage-adjacent groups, S1, S2, S3, and S4 are, respectively, B KLF17, C FAM46C, D GSN, E CAPN2. Gene ontology function of the top ten similarly positioned genes from this integrated UMAP analysis for each of the four developmental groups is found in Additional file 2: Table S13

Back to article page