Sex-specific associations of matrix metalloproteinases in Alzheimer’s disease

Table 3 Adjusted effects of A− and T-status on MMP- and TIMP-levels in CU controls and patients

Dependent variable/independent variable	MMP-2	MMP-3	MMP-10	TIMP-1	TIMP-2	TIMP-3	TIMP-4
A+ status	− 0.13	− 0.18*	− 0.07	− 0.14	− 0.11	− 0.19	− 0.25**
T+ status	0.24**	0.39**	0.37**	0.16**	0.16**	0.17**	0.43**
Age	0.31**	0.11*	0.13**	0.36**	0.22**	0.11*	0.05
Male sex	0.32**	0.18**	0.20**	0.26**	0.34**	0.27**	0.04
APOE ε4 carrier	0.05	0.06	0.08	0.13*	0.05	0.10	0.14*
MCI (vs. CU)	0.07	0.09	0.16*	0.01	0.26**	0.07	0.16*
Dementia (vs. CU)	0.00	0.19	0.33**	0.10	0.35**	0.16	0.12
Adjusted R²	0.28	0.20	0.29	0.23	0.24	0.11	0.19

Standardised β-coefficients are presented. *P < 0.05, ** P < 0.01. A+: biomarkers positive for Aβ pathology, APOE: apolipoprotein E, CU cognitively unimpaired, MCI mild cognitive impairment, MMP matrix metalloproteinase, T+: biomarkers positive for tau pathology, TIMP tissue inhibitor of matrix metalloproteinase

ISSN: 2042-6410