Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson’s disease

Table 2 Moderated moderation models showing three-way interactions between motor symptom asymmetry, UA and sex on cognitive and psychiatric outcomes at 1-year follow-up

	B	SE	95% CI
Model 1: three-way interactions on HVLT immediate recall
LPD × UA	0.060	0.031	− 0.002	0.122
RPD × UA	− 0.016	0.034	− 0.083	0.051
LPD × sex	− 2.40	1.99	− 6.31	1.52
RPD × sex	0.25	2.34	− 4.36	4.86
UA × sex	0.015	0.010	− 0.004	0.034
LPD × UA × sex	− 0.056	0.026	− 0.107	− 0.005*
RPD × UA × sex	0.005	0.029	− 0.051	0.062
Model 2: three-way interactions on HVLT delayed recall
LPD × UA	0.038	0.015	0.009	0.067*
RPD × UA	− 0.008	0.018	− 0.044	0.028
LPD × sex	− 1.137	0.886	− 2.88	0.605
RPD × sex	− 0.244	1.11	− 2.44	1.95
UA × sex	0.006	0.005	− 0.003	0.016
LPD × UA × sex	− 0.034	0.011	− 0.0553	− 0.012*
RPD × UA × sex	0.002	0.016	− 0.030	0.033
Model 3: three-way interactions on SDMT
LPD × UA	0.021	0.060	− 0.097	0.138
RPD × UA	− 0.106	0.060	− 0.224	0.013
LPD × sex	− 2.43	3.30	− 8.93	4.06
RPD × sex	6.49	3.83	− 1.05	14.03
UA × sex	0.000	0.027	− 0.053	0.053
LPD × UA × sex	− 0.019	0.043	− 0.105	0.067
RPD × UA × sex	0.101	0.047	0.009	0.193*
Model 4: three-way interactions on ESS
LPD × UA	0.003	0.026	− 0.048	0.053
RPD × UA	0.035	0.022	− 0.008	0.078
LPD × sex	0.054	1.78	− 3.45	3.56
RPD × sex	− 3.45	1.37	− 6.15	− 0.748*
UA × sex	0.001	0.008	− 0.015	0.017
LPD × UA × sex	0.007	0.022	− 0.036	0.050
RPD × UA × sex	− 0.036	0.016	− 0.067	− 0.005*

Model includes the following demographic control variables: age, education, levodopa medication and racial background
B Unstandardized regression coefficient, CI Confidence Intervals, ESS Epworth Sleepiness Scale, HVLT Hopkins Verbal Learning Test, LPD patients with Parkinson’s disease (PD) who exhibit predominantly left-sided motor symptoms, RPD patients with PD who exhibit predominantly right-sided motor symptoms, SE standard error of the regression, SDMT Symbol Digit Modalities test, UA uric acid
Statistically significant relationships where p < 0.05 are reported with an asterisk

ISSN: 2042-6410