Fig. 5
From: Neurobehavioral sex-related differences in Nf1+/− mice: female show a “camouflaging”-type behavior
Female Nf1+/− mice show surprisingly better spatial memory performance in opposition with the effect found in male Nf1+/− mice. a Regarding time spent in platform quadrant during probe phase, our results demonstrated that mutant mice showed an impairment in spatial memory (*p < 0.05, comparing with their littermates WT). Interestingly, female Nf1+/− mice have better performance by spending more time in this quadrant (**p < 0.01, comparing with their littermates WT; ****p < 0.001, comparing with male Nf1+/− mice). b, c No changes were detected between groups in distance travelled and mean speed during probe phase. d Representative image of path length of Morris water maze test. Data are expressed as mean ± SEM, n = 3–7. Statistical significance was found by two-way ANOVA followed by Tukey’s multiple comparisons test