Fig. 2
From: Neurobehavioral sex-related differences in Nf1+/− mice: female show a “camouflaging”-type behavior
Male Nf1+/− mice display hippocampal morphological changes. a Both female and male Nf1+/− mice showed an increase in index brain weight/body weight (*p < 0.05, **p < 0.01 compared with their littermates WT). b Further, transgenic males display higher volume of the hippocampus (*p < 0.05, compared with their littermates WT and with mutant females). Females did not show any differences. c Representation of hippocampus mask using in volume measurement by ITK-SNAP software. d When we analyzed the thickness of hippocampal subregions, transgenic males exhibited thicker CA1 and DG granule cell layers (**p < 0.01, compared with female Nf1+/− mice). Interestingly, CA3 sub-region presented a sexual dimorphism in WT animals (**p < 0.01, compared with female WT mice) that was not observed in Nf1+/− mice. Data are expressed as mean ± SEM, n = 3–10. Statistical significance was found by two-way ANOVA followed by Tukey’s multiple comparisons test