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Fig. 6 | Biology of Sex Differences

Fig. 6

From: Sex differences in the transcriptome of extracellular vesicles secreted by fetal neural stem cells and effects of chronic alcohol exposure

Fig. 6

WCGNA-based Relationship between EV – Cell Consensus Modules and Sample Traits. A Schematic diagram of the relationship between eigengenes from consensus modules and sample trait of ‘Sex’ (as a trait example) in EV or Cell data sets. B–D Color-coded heatmaps of Consensus module relationship to sample traits of ‘Sex’ and Pregnancy’ in EV samples (B), Cell samples (C), or across both EV and cell samples (D). The rows depict Consensus module eigengenes (MEs) and their unique module color identities, while the columns depict the sample traits, ‘Sex’ and ‘Pregnancy’. Numbers in the table correspond to the correlation coefficients between the ME and the specific trait, with p-value in parentheses. The strength and direction of correlation is represented by a color scale, where red indicates positive and green indicates negative correlation with a trait. For ‘D’, consensus module–trait relationships across EV and cell samples were constructed by taking the lower absolute value of each module’s correlation coefficient from the two data sets if the two correlations have the same sign. Correlation coefficients were set to ‘NA’, and color-coded to grey, when the two correlations had opposite signs. Yellow asterisks within grey-coded cells indicate that the sample trait correlation with eigengene was significant in either Cell or EV dataset. In both EV and Cell samples, there were significant correlations between consensus modules and sample traits of ‘Pregnancy’ and ‘Sex’, though the correlation was in the opposite direction for cells and EVs

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