BDNF genotype | Usual care plus education group | Aerobic training group | p value | ||||||
---|---|---|---|---|---|---|---|---|---|
Males | Females | Males | Females | ||||||
Val/Val | Met | Val/Val | Met | Val/Val | Met | Val/Val | Met | ||
Descriptive variables | |||||||||
 n | 8 | 7 | 6 | 6 | 10 | 4 | 14 | 3 |  |
 Age, year | 74.4 (9.9) | 76.3 (8.7) | 70.3 (4.3) | 74.2 (4.9) | 76.6 (9.0) | 68.3 (8.1) | 72.9 (6.9) | 75.7 (7.2) | 0.316 |
 Functional comorbidity index | 4.1 (2.9) | 3.3 (1.6) | 3.8 (2.6) | 4.0 (2.6) | 3.6 (1.3) | 1.5 (1.3) | 3.5 (1.3) | 3.0 (2.6) | 0.804 |
 Waist to hip ratio | 0.96 (0.03) | 0.95 (0.04) | 0.86 (0.08) | 0.91 (0.08) | 0.94 (0.07) | 0.90 (0.05) | 0.83 (0.06) | 0.82 (0.10) | 0.798 |
 Body Mass Index, kg/m2 | 26.8 (2.1) | 27.3 (3.0) | 27.4 (2.9) | 24.7 (5.1) | 26.7 (3.7) | 25.8 (5.2) | 24.6 (3.4) | 25.5 (2.8) | 0.223 |
 Weight (kg) | 81.7 (7.0) | 81.6 (9.4) | 69.7 (7.6) | 57.9 (13.0) | 83.8 (10.5) | 80.1 (13.5) | 60.0 (8.9) | 69.4 (10.2) | 0.033 |
 Resting heart rate, bpm | 71.3 (19.1) | 62.7 (14.7) | 73.0 (18.7) | 75.3 (11.6) | 67.2 (14.6) | 63.0 (20.5) | 67.6 (9.8) | 70.3 (14.2) | 0.820 |
 Short physical performance battery | 10.3 (0.9) | 10.3 (1.7) | 10.7 (0.8) | 11.2 (0.8) | 10.9 (1.3) | 12.0 (0.0) | 10.5 (1.8) | 11.7 (0.6) | 0.791 |
 Timed Up-and-Go Test, sec | 8.4 (1.9) | 9.6 (4.1) | 8.1 (1.3) | 7.6 (1.5) | 8.8 (1.9) | 7.7 (1.3) | 8.4 (2.3) | 7.5 (1.8) | 0.491 |
 Physical activity scale for the elderly | 122.9 (62.4) | 118.3 (59.9) | 145.9 (40.9) | 130.4 (59.1) | 125.9 (110.9) | 137.1 (22.6) | 133.8 (65.2) | 85.6 (26.8) | 0.553 |
 6-Minute Walk Test, m | 461.6 (96.3) | 480.0 (105.9) | 528.0 (79.7) | 516.5 (109.9) | 520.1 (87.7) | 575.8 (92.0) | 488.0 (87.9) | 578.0 (98.1) | 0.559 |
 Geriatric Depression Scale | 2.9 (2.0) | 2.4 (2.5) | 1.67 (1.9) | 1.67 (1.4) | 2.2 (2.8) | 1.0 (2.0) | 2.3 (2.4) | 2.0 (1.7) | 0.860 |
Cognitive variables | |||||||||
 Mini-Mental State Examination | 26.5 (2.9) | 26.4 (2.9) | 28.0 (1.4) | 27.7 (1.6) | 25.4 (3.0) | 26.8 (1.7) | 27.1 (2.7) | 25.7 (3.1) | 0.414 |
 Montreal Cognitive Assessment | 23.0 (2.6) | 22.1 (3.8) | 23.2 (2.5) | 22.7 (3.1) | 21.1 (3.9) | 22.5 (0.6) | 20.6 (2.6) | 19.7 (4.0) | 0.447 |
 Trail Making Test B–A, sec | 93.9 (117.9) | 58.0 (18.0) | 56.7 (38.3) | 55.7 (27.9) | 58.8 (65.8) | 55.4 (15.6) | 59.4 (31.1) | 23.3 (6.9) | 0.315 |
 Digit Symbol Substitution Test | 23.4 (3.5) | 24.1 (4.0) | 29.5 (9.4) | 23.5 (7.6) | 20.8 (5.3) | 25.3 (9.8) | 28.4 (7.8) | 29.3 (7.6) | 0.689 |