Fig. 4

Cpt1aKO mice display changes in thirst behavior. a, e 24 h of urine collection in female (a, n = 6–5) and male mice (e, n = 6–7). b, f Analysis of urine osmolality in female (b, n = 11–8) and male mice (f, n = 16–9) under 24 h of water restriction or ad libitum access to water; ND, not detected. c, g Total amount of water intake for 24 h in female (c, n = 6–7) and male mice (g, n = 6–5). d, h Analysis of serum osmolality in female (d, n = 10–5) and male mice (h, n = 9–6) under 24 h of water restriction or ad libitum access to water. i Plasma level of the vasopressin hormone in female (n = 8–8) and male mice (n = 9–6). j, n Plasma levels of renin in female (j, n = 5) and male mice (n, n = 7–9). k, o Plasma levels of angiotensin II in female (k, n = 10–8) and male mice (o, n = 9–6). l, p Plasma levels of aldosterone in female (l, n = 8) and male mice (p, n = 8–10). m, q Blood pressure in female (m, n = 5–5) and male mice (q, n = 8–8). Data are expressed as the mean ± SEM. In b, d, f, h, i, **p < 0.01, ****p < 0.0001 using two-way repeated-measures ANOVA followed by the post hoc Bonferroni test. In a, c, e, g, j–o, *p < 0.05, **p < 0.01, ***p < 0.001, using Student’s t-test