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Table 2 Neurological diseases and functions associated with AR target genes that were differentially expressed in the hippocampus of male offspring prenatally exposed to BPA

From: Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus

Diseases or functions

p values

Genes

Number of genes

Neurological disorders

 Autism spectrum disorder or intellectual disability

1.04E−07

Adnp, Chd2, Cic, Dst, Gria3, Kirrel3, Kmt2b, Kmt2c, Kmt2d, Mef2c, Nipbl, Nsd1, Slc25a12, Snap25, Sptan1, Syncrip, Tnrc6c, Wdfy3, Zic1, Zmynd8

20

 Microcephaly

1.16E−05

Adnp, Hspg2, Kmt2c, Kmt2d, Nsd1, Sptan1, Tp53bp1, Trps1, Wdfy3

9

 Growth failure or short stature

3.08E−05

Ckb, Eif2ak3, Hspg2, Itpkb, Jup, Kdm2a, Kmt2b, Kmt2c, Lrp1, Mef2c, Tial1, Tp53bp1, Trps1, Txnip, Zic1

15

 Abnormal morphology of embryonic tissue

9.06E−05

Adnp, Epn1, H2az1, Itgb8, Jup, Kdm2a, Kmt2b, Mef2c, Nsd1, Pam, Pou3f3, Zfpm1

12

 Pervasive developmental disorder

1.42E−04

Adnp, Dst, Kirrel3, Kmt2b, Mef2c, Slc25a12, Syncrip, Wdfy3

8

 Global developmental delay

1.75E−04

Adnp, Elavl2, Gria3, Kmt2b, Nipbl, Pou3f3, Snap25

7

Nervous system development and functions

 Proliferation of neuronal cells

1.87E−05

Adnp, Dagla, Epha2, Epn1, Erbb4, Kdm2a, Map1b, Otp, Pkp4, Sema4c, Snap25, Spock2, Zfyve26

13

 Developmental process of synapse

1.97E−04

Adnp, Caprin1, Epha7, Erbb4, Kirrel3, Mef2c, Slitrk1

7

 Excitatory postsynaptic potential

8.25E−04

Caprin1, Gria3, Mef2c, Rims2, Snap25

5

 Docking of synaptic vesicles

1.36E−03

Rims2, Snap25

2

 Neuritogenesis

1.55E−03

Caprin1, Ckb, Csmd3, Epha7, Erbb4, Kirrel3, Lrp1, Map1b, Neo1, Pkp4, Slitrk1

11

Behaviors

 Abnormal posture

5.75E−04

Caprin1, Eif2ak3, Trps1, Zfyve26

4

 Cognition

3.13E−03

Adnp, Cic, Ckb, Erbb4, Kmt2b, Kmt2d, Nipbl, Snap25, Zfpm1

9

  1. Biological functions and diseases associated with AR transcriptional targets that were differentially expressed in the hippocampus of male offspring prenatally exposed to BPA were predicted using IPA software. Statistical significance was determined using Fisher’s exact test. A p value < 0.05 was considered significant