Table 1 Hypergeometric distribution analysis of transcriptional targets of ASD-related TFs and BPA-responsive genes in the hippocampus of male and female offspring
| Â | Male (2078 DEGs) | Female (3055 DEGs) | Both sexes (4525 DEGs) | ||||||
|---|---|---|---|---|---|---|---|---|---|
TFs | TRANSFAC Curated p value (#overlapping genes/#targets) | TRANSFAC Predicted p value (#overlapping genes/#targets) | CHEA p value (#overlapping genes/#targets) | TRANSFAC Curated p value (#overlapping genes/#targets) | TRANSFAC Predicted p value (#overlapping genes/#targets) | CHEA p value (#overlapping genes/#targets) | TRANSFAC Curated p value (#overlapping genes/#targets) | TRANSFAC Predicted p value (#overlapping genes/#targets) | CHEA p value (#overlapping genes/#targets) |
AR | 0.038 (96/755) | NA | 0.999 (595/6279) | 0.574 (135/755) | NA | 0.999 (1011/6279) | 0.994 (179/755) | NA | 0.999 (1536/6279) |
ESR1 | 0.027 (63/465) | NA | 0.692 (234/2253) | 0.426 (86/465) | NA | 0.235 (420/2253) | 0.854 (119/465) | NA | 0.730 (611/2253) |
EGR2 | 0.560 (20/190) | NA | NA | 0.044 (44/190) | NA | NA | 0.685 (50/190) | NA | NA |
KDM5B | NA | NA | 2.06E−07 (463/3555) | NA | NA | 2.90E−05 (725/3555) | NA | NA | 0.985 (932/3555) |
SOX5 | 6.16E−04 (45/258) | NA | NA | 0.029 (59/258) | NA | NA | 0.892 (63/258) | NA | NA |
SMAD4 | 0.435 (26/233) | 0.033 (338/2904) | 0.125 (493/4430) | 0.337 (45/233) | 0.072 (553/2,904) | 0.890 (775/4430) | 0.997 (47/233) | 0.999 (703/2904) | 0.999 (1140/4430) |
TCF7L2 | NA | NA | 0.826 (54/565) | NA | NA | 0.311 (107/565) | NA | NA | 0.040 (175/565) |
YY1 | 0.020 (97/744) | 0.961 (151/1,602) | 0.660 (260/2488) | 0.087 (149/744) | 0.970 (263/1602) | 0.997 (402/2488) | 0.986 (180/744) | 0.999 (391/1602) | 0.999 (598/2488) |