Fig. 8
From: Sex differences in hearing impairment due to diet-induced obesity in CBA/Ca mice
Local and periphery IL-1β and cochlear blood flow. a A proinflammatory cytokine, IL-1β, was quantified by ELISA in the whole cochlear lysates at 14 weeks of diet treatment. A significant main effect of sex (F1, 31 = 4.692, p = 0.0381, Two-way ANOVA), but no main effect of diet (F2, 31 = 0.7817, p = 0.4664) was observed. b Peripheral inflammation was measured in the liver IL-1β. A 60% fat diet increased IL-1β in male mice. Two-way ANOVA with Tukey’s multiple comparisons test. p < 0.05. a, main effect of sex; b, main effect of diet. c The cochlear blood flow was measured at 14 wks of age from male and female mice after feeding diets for 10 weeks. HFD-induced obesity impacts the cochlear microcirculation in the male mice. Two-way ANOVA with Fisher’s LSD. p < 0.05. amain effect of sex; bmain effect of diet. *p < 0.05; **p < 0.01